NCT03005080已完成不适用
The Utility of Pharmacogenetic Testing in Managing Children With Persistent Gastroesophageal Reflux Disease Despite Therapy
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- Number of subjects who change medication due to pharmacogenomic results
研究概览
简要总结
This study will use a 22 gene pharmacogenomics panel on 30 children with persistent Gastroesophageal Reflux Disease (GERD) who have not responded to therapy.
详细描述
This study will assess the clinical utility of pharmacogenomics testing in the clinical management of children with refractory GERD, despite adequate therapy and the role of pharmacogenomics in selecting the right acid suppressive therapy based on each patient's symptoms and pharmacogenomics results.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •persistent gastrointestinal symptoms (GI) suggestive of gastro esophageal reflux disease (GERD) despite adequate therapy
- •persistent evidence of abnormal reflux indices' and acid exposure on esophageal multichannel pH impedance study despite adequate therapy
- •persistent endoscopic evidence of reflux esophageal disease despite adequate therapy
排除标准
- •children with eosinophilic esophagitis diagnosis
- •children with any esophageal surgical intervention like fundoplication, tracheoespahgeal fistula repair or esophageal atresia repair
- •children with other diseases that can affect the esophagus, like Crohn's disease or food protein-induced enterocolitis syndrome (F-PIES)
- •Children who do not have research authorization in their chart
结局指标
主要结局
Number of subjects who change medication due to pharmacogenomic results
时间窗: 12 weeks
Number of subjects who have a repeat scope
时间窗: 12 weeks
次要结局
未报告次要终点
研究者
研究点 (1)
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