Genetic Variations,Immuno-sequencing and Circulating Tumor DNA(ctDNA) for Early Diagnosis of Small Pulmonary Nodules
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- The sensitivity and specificity of combining peripheral plasma circulating tumor DNA and white cell immuno-sequencing in diagnosis of early stage non-small cell lung cancer
研究概览
简要总结
Analyse immune repertoire and genetic mutations of benign and malignant pulmonary nodule，and evaluate peripheral blood detection for identifying nature of pulmonary nodule.
详细描述
Early diagnosis of lung cancer is of vital importance in lung cancer treatment. This research will first analyse the features of immune repertoire and genetic mutations from tissue of benign and malignant pulmonary nodule，then explore the feasibility of detecting these features from peripheral blood sample, and finally evaluate peripheral blood detection of lung cancer related immune repertoire and genetic mutations for identifying nature of pulmonary nodule.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Sign informed consent and consent to participate in this study;
- •Found small nodules in pulmonary by CT and prepare for surgery;
排除标准
- •Malignant tumor history within the past 5 years;
- •Receiving chemotherapy, radiotherapy or targeted therapy before surgery;
- •Histology confirmed not non-small cell lung cancer
- •No matching tissue or blood samplesUnqualified blood samples
结局指标
主要结局
The sensitivity and specificity of combining peripheral plasma circulating tumor DNA and white cell immuno-sequencing in diagnosis of early stage non-small cell lung cancer
时间窗: 6 months
次要结局
- The sensitivity and specificity of tissue immune repertoire in diagnosis of early stage non-small cell lung cancer(6 months)
- The concordance of peripheral plasma circulating tumor DNA and tumor tissue DNA in diagnosis of early stage non-small cell lung cancer(6 months)
研究者
Jun Wang
Chief，Thoracic Surgery Service
Peking University People's Hospital