Chemokine Receptor 4 PET/CT Imaging of CXCR4-Related Diseases
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 3
- 主要终点
- Standardized uptake value (SUV)
研究概览
简要总结
To evaluate the potential usefulness of 68Ga/18F-Pentixafor/Pentixather positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various CXCR4-related disease patients.
详细描述
Subjects with various CXCR4-related disease patients underwent 68Ga/18F-Pentixafor/Pentixather PET/CT either for an initial assessment or for recurrence detection. Lesions uptake was quantified by the maximum standard uptake value (SUVmax). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of 68Ga/18F-Pentixafor/Pentixather PET/CT were calculated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •suspected or confirmed untreated Lymphoproliferative and other CXCR4-related diseases patients
- •18F-FDG PET/CT within two weeks
- •signed written consent.
排除标准
- •pregnancy
- •breastfeeding
- •known allergy against Pentixafor
研究组 & 干预措施
CXCR4 PET/CT Imaging
Intravenous injection of one dose of 2-5 mCi 68Ga/18F-Pentixafor/Pentixather. Tracer doses of radiotracers will be used to image lesions by PET/CT
干预措施: CXCR4 PET/CT Imaging (Diagnostic Test)
结局指标
主要结局
Standardized uptake value (SUV)
时间窗: 30 days
Standardized uptake value (SUV) of FAPI for each target lesion of subject or suspected primary tumor or/and metastasis.
次要结局
- Diagnostic efficacy(30 days)
研究者
Shaobo Yao, PhD
Prof.
Tianjin Medical University