Efficiency of Low Level Laser Therapy and Ozone on Sequelae After Extraction of Impacted Mandibular Third Molar
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- pain
研究概览
简要总结
Many factors cause third molars to stay impacted in the jaws, hence the extraction of impacted wisdom teeth occurs often in dental clinics. Pain, trismus, and edema are typical postoperative complications following third molar surgery. Various strategies have been developed to prevent or reduce these postoperative complications, Among these is the use of Low-Level Laser Therapy (LLLT), which demonstrates numerous benefits in lowering pain, trismus, and edema by managing inflammation. The precise biological mechanism of action remains unknown. There seems to be evidence that it may have neuro-pharmacological impacts on the production, metabolism, and release of a number of biological compounds, the other option is use of ozone which has antimicrobial effectiveness (viricidal, bactericidal, and fungicidal). Additional well-known advantages include immunological modulatory and stimulating actions, including anti-inflammatory, biosynthetic, anti-hypoxic, and bioenergetic characteristics. Ozone can interact with blood components in the right amounts to positively impact oxygen metabolism and cell energy while also triggering antioxidant defense mechanisms
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 38 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients who had mandibular third molar, totally or partially impacted in the bone (Class II-III and position B, Pell and Gregory's classification), in need of surgical extraction, which were evaluated clinically and by radiological examination.
- •Patients who were in age range between 18-40 years old.
- •Patients who were willing to compliance with study and were available for follow up.
- •Patients should be with good oral hygiene and without any acute illness
排除标准
- •Patients with medical condition that prevent any surgical intervention such as patient with recent myocardial infarction, bleeding disorders, psychiatric problem and patients with pacemaker, uncontrolled systemic disease, immunocompromised patient and patients taking corticosteroid and anti-inflammatory drugs.
- •Patients with history of head and neck radiotherapy.
- •Pregnant or lactation women
- •Active advanced uncontrolled periodontal disease and bad oral hygiene, or patients with local acute infection in relation to third molar especially pericoronitis.
- •Patients who suffer from photodermatoses and photosensitized patients (photoallergies).
- •Hyperthyroidism
研究组 & 干预措施
LLLT and ozone group
administered of low level laser therapy and ozone gel after extraction of impacted mandibular third molar
干预措施: low level laser therapy (Radiation)
LLLT and ozone group
administered of low level laser therapy and ozone gel after extraction of impacted mandibular third molar
干预措施: ozone gel (Drug)
LLLT group
administered of low level laser therapy after extraction of impacted mandibular third molar
干预措施: low level laser therapy (Radiation)
ozone group
administered of low ozone gel after extraction of impacted mandibular third molar
干预措施: ozone gel (Drug)
结局指标
主要结局
pain
时间窗: baseline to seventh day
measurement of pain by NRS, between 0 and 10, zero meaning no pain and 10 meaning worst imaginable pain
trismus
时间窗: baseline to seventh day
measurement of maximum mouth opening by using digital Vernia
swelling
时间窗: baseline to seventh day
measurement of swelling by using tape, using 3 lines
次要结局
未报告次要终点
研究者
Osama Abdulkathim Ali
postgraduate student
University of Baghdad
