The influence of multimodal physical activity on cognition and everyday life competence in patients with early Alzheimer's disease - Sport & KOG

niversitätsklinikum EssenUniversität Duisburg-Essen0 个研究点目标入组 300 人开始时间: 2009年3月24日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•diagnosis of Alzheimer's dementia according to NINCDS-ADRDA respectively ICD 10
•-Mini-Mental-State-Test (20 - 25) at screening
•-Hachinski Ischemia Scale <=4 at screening
•-CT or MRT, maximal 2 years old, compatible with Alzheimer's dementia
•-Geriatric Depression Scale (GDS) <=4 (15-item scale)
•-ambulant patients
•-exercise ECG analysed by specialist in internal medicine
•-caregiver (contact 3 times a week, overall 5 hours a week), who can report the patient's state of health
•-informed consent form signed by patient and caregiver

•-diagnosis of a possible, probable or certain vascular dementia NINDS-AIREN criteria
•-missing approval ability, missing ability to take part in intervention programme or missing compliance
•-intake of following drugs with change of dosage during the last 3 months before baseline: antidepressants, tranquilizer / sleeping pills, anti-psychotica or anti-epileptica
•-excessive alcohol, drug or medicament abuse. Diagnosis of drug abuse or drug addiction (ICD-10) as a primary clinical diagnosis, which indicates the initiation or continuation of a medical treatment of this disorder
•-clinically relevant neurologic or psychiatric diseases, such as severe depression, schizophrenia, epilepsy or Parkinson's disease
•-participation in a pharmaceutical trail 2 months before baseline
•-decompensated or poorly regulated diabetes
•-decompensated or poorly regulated hypertonia
•-cardiovascular event during the last 3 months e.g. cardiac catheterization, vascular surgery, acute coronary syndrome, myocardial infarction or unstable angina, clinical relevant cardiac dysrhythmia, cardiac surgery, angiography with stent implantation
•-other clinically significant aberrances in clinical, neurologic, laboratory medicine examination, clinically relevant ECG changes, which could impair the patient's health related to the trail
•-cardiologically relevant anaemia

发起方

niversitätsklinikum EssenUniversität Duisburg-Essen