NCT02294539已完成4 期
Comparison of Effects Between Calcium Channel Blocker and Diuretics in Combination With Angiotensin II Receptor Blocker on 24-hr Central Blood Pressure and Vascular Hemodynamic Parameters in Hypertensive Patients Multicenter, Double-blind, Active-controlled, Phase 4 Randomized Trial
Chong-Jin Kim1 个研究点 分布在 1 个国家目标入组 231 人开始时间: 2014年8月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 231
- 试验地点
- 1
- 主要终点
- change from baseline in msSBP
研究概览
简要总结
The purpose of this study is to investigate which combination therapy is more effective for improving the blood pressure (BP) and AM central SBP in hypertensive patients:Angiotensin II receptor blocker (ARB) plus calcium channel blocker (CCB) or ARB plus diuretics
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hypertension patients not included exclusion criteria
- •Mean seated SBP ≥140mmHg in patients with newly Diagnosed
排除标准
- •msDBP≥110mmHg or ms SBP ≥ 180mmHg at the screening and randomization visit
研究组 & 干预措施
Losartan 50mg/amlodipine 5mg
Experimental
Once daily, 1T, PO medication
干预措施: Losartan 50mg/Hydrochlorothiazide 12.5mg (Drug)
Losartan 100mg/amlodipine 5mg
Experimental
Once daily, 1T, PO medication
干预措施: Losartan 100mg/Hydrochlorothiazide 25mg (Drug)
Losartan50 mg/Hydrochlorothiazide12.5 mg
Active Comparator
Once daily, 1T, PO medication
干预措施: Losartan 50mg/amlodipine 5mg (Drug)
Losartan100 mg/Hydrochlorothiazide25 mg
Active Comparator
Once daily, 1T, PO medication
干预措施: Losartan 100mg/amlodipine 5mg (Drug)
结局指标
主要结局
change from baseline in msSBP
时间窗: 4 weeks
次要结局
- change from baseline in AMcSBP(20 weeks)
研究者
Chong-Jin Kim
Chairman of Cardiovascular Center
Kyung Hee University Hospital at Gangdong
研究点 (1)
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