The Mysterious on/Off Itch and Erythema During Whole Body Vibration Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Itch intensity
研究概览
简要总结
Intense itch on the legs sometimes associated with redness can be adverse effects of whole body vibration (WBV) according to own observations and numerous posts in non-professional online-blogs. To the investigators' knowledge, the appearance of itch and/or a rash during WBV exercise has not yet been described.
The research objectives are:
- To determine the effect of WBV on itch rating and its unpleasantness and on skin changes.
- To determine the effect of WBV on immunoglobulin E (IgE) and serum tryptase
详细描述
Objectives Intense itch on the legs sometimes associated with redness can be adverse effects of WBV according to the investigators observations and numerous posts in non-professional online-blogs. To the investigators knowledge, the appearance of itch and/or a rash during WBV exercise has not yet been described.
The objectives of this study are:
- to determine the effect of WBV on itch rating and its unpleasantness and on skin changes.
- to determine the effect of WBV on serum tryptase.
Hypothesis The working hypothesis is that repeated WBV leads to an increase of itching and erythema. Further investigators hypothesize that repeated WBV does not lead to an increase in serum tryptase.
Inclusion and exclusion criteria will be evaluated. Subjects will be instructed to not shave their legs one week before the intervention day and to shave only the left leg from the ankle to the knee on the day prior to the intervention day.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •age 18-35 years
- •Informed Consent as documented by signature (Appendix Informed Consent Form)
排除标准
- •itchy skin diseases
- •hay fever
- •chronic venous insufficiency
- •peripheral artery disease
- •musculoskeletal diseases or injuries affecting the legs, hips and pelvis
- •BMI < 17 and > 35 kg/m2
- •pregnancy
研究组 & 干预措施
Whole body vibration training
Healthy female subjects complete whole body vibration training (10 x 1 min exposure)
干预措施: Whole body vibration training (Other)
结局指标
主要结局
Itch intensity
时间窗: 0 months
0 to 10 numerical rating scale (NRS) (best score: 0 - no itch; worst score: 10)
次要结局
- Itch characteristics(0 months)
- Skin surface temperature(0 months)
- Itch unpleasantness(0 months)
- Erlanger atopy score(0 months)
- Erythema intensity(0 months)
- Total immunoglobulin E (IgE) concentration(0 months)
- Tryptase concentration(0 months)