NCT01427140已完成不适用
Metabolic Consequences of Moderate Weight Gain - Role of Dietary Fat Composition (LIPOGAIN): a Randomized Double-Blind Controlled Study
Uppsala University1 个研究点 分布在 1 个国家目标入组 41 人开始时间: 2011年9月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 41
- 试验地点
- 1
- 主要终点
- Hepatic steatosis by magnetic resonance tomography (MRT)
研究概览
简要总结
The purpose of this study is to investigate the metabolic consequences of a moderate weight gain and if the type of dietary fat (saturated versus polyunsaturated) can modify the effects in young healthy adults. Hypothesis: the type of dietary fat can modify the effects of weight gain.
详细描述
Specific goals:
- Investigate if dietary fat composition influences liver fat accumulation and metabolic risk factors in response to moderate weight gain
- Investigate if polyunsaturated fat (PUFA) in the diet could counteract any unfavorable metabolic changes that are expected to accompany moderate weight gain
- Investigate effects of weight gain and dietary fat composition on markers of vascular health
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 38 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Body Mass Index 18-27
排除标准
- •Liver disease,
- •Coronary heart disease,
- •Diabetes mellitus,
- •Malignant diseases,
- •Alcohol or drug abuse,
- •Magnetic Resonance-incompatibility,
- •Abnormal clinical chemistry,
- •Use of drugs that significantly effects energy metabolism,
- •Heavy exercise,
- •Pregnancy or lactation,
- •Allergy of gluten, egg or milk protein
结局指标
主要结局
Hepatic steatosis by magnetic resonance tomography (MRT)
时间窗: 6 weeks
次要结局
- Apolipoprotein B (ApoB)(6 weeks)
- Apolipoprotein A1 (ApoA1)(6 weeks)
- Triglycerides(6 weeks)
- Cholesterol(6 weeks)
- high density lipoprotein (HDL)(6 weeks)
- low density lipoprotein (LDL)(6 weeks)
- Insulin(6 weeks)
- Glucose(6 weeks)
- Aspartate aminotransferase (ASAT)(6 weeks)
- Alanine aminotransferase (ALAT)(6 weeks)
- Gamma glutamyl transpeptidase (GGT)(6 weeks)
- Homeostasis model of assessment insulin resistance (HOMA-IR)(6 weeks)
- C-reactive protein (CRP)(6 weeks)
- Proinsulin(6 weeks)
- Endostatin(6 weeks)
- Pentraxin-3 (PTX-3)(6 weeks)
- Endothelin-1 (ET-1)(6 weeks)
- E-selectin(6 weeks)
- Cathepsin-S(6 weeks)
- Cystatin C(6 weeks)
研究者
研究点 (1)
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