NCT05283876已完成不适用
Excimer Light Effect on Neurogenic Inflammation in Developing Versus Stationary Psoriasis Lesions
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Excimer laser efficiency in active and stable psoriasis
研究概览
简要总结
The aim of this study is to determine the standard tissue levels of SP and its receptor in lesional skin of psoriasis patients in both developing and stationary stages before and after excimer light therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type of Psoriasis: plaque psoriasis.
- •Less than 10% surface area.
排除标准
- •Erythrodermic psoriasis
- •Pustular psoriasis
- •Topical treatment for psoriasis for the past 2 weeks.
- •Systemic retinoids in the last 2 years.
- •Systemic treatments (including any drugs that affect SP level as Aprepitant) in the last 3 months.
- •Contraindications to excimer light therapy (history of skin malignancy or precancerous conditions like xeroderma pigmentosum or photosensitivity)
结局指标
主要结局
Excimer laser efficiency in active and stable psoriasis
时间窗: through study completion, an average of 6 months
Determine the clinical improvement using Local psoriasis severity index
Excimer laser efficiency on neurogenic inflammation
时间窗: through study completion, an average of 6 months
level of affection of the neurogenic inflammation in psoriasis lesions after using Excimer light therapy. Determine substance P and its receptor levels before and after therapy.
次要结局
未报告次要终点
研究者
Marwa Salah El-Din El-Mesidy
Dr.
Cairo University
研究点 (1)
Loading locations...
相似试验
已完成
1 期
Effects of High-concentration Topical Capsaicin on Histaminergic and Non-histaminergic ItchPruritusNCT02769910Hjalte Holm Andersen16
已完成
不适用
Chasing Biomarkers in Post-concussion SyndromePost Concussive SymptomsNCT05812742University of Aarhus86
招募中
不适用
TSPO-PET/MRI in Surveillance of Neuroinflammation in the Central Nervous SystemCentral Nervous System DiseasesNCT06467773Tongji Hospital100
已完成
不适用
Dysregulated CNS Inflammation After Acute Brain InjuryTraumatic Brain InjuryAneurysmal Subarachnoid HemorrhageNCT03287557University of Kentucky8
招募中
不适用
Analysis of the role of neuroinflammation in the genesis of ischemic strokes.I63Cerebral infarctionDRKS00013278niversitätsklinikum BG Bergmannsheil GmbH, Abteilung für Neurochirurgie und -Traumatologie200