Registry of Right-to-left Shunt Detection by Contrast-enhanced Transcranial Doppler in Chinese Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,100
- 试验地点
- 1
- 主要终点
- contrast-enhanced transcranial Doppler
研究概览
简要总结
The purpose of the study is to evaluate the prevalence and extent of right-to-left shunt (RLS) in Chinese migraineurs, and the morbidity of silent cerebral infarction in migraineurs.
详细描述
This is a prospective multicenter study of Chinese population. Participants (normal individuals without migraine and migraineurs) are included after standardized diagnostic procedures (TCD and c-TCD). For migraineurs with large RLS further examinations (c-TTE and brain MRI) are required. Up to 10 study sites nationwide will be needed to recruit the planned participant population during a 1-year period.
The information of each participants will be registered, including basic facts, the longitudinal headache history, frequency, location, quality, intensity, duration, accompanied symptoms, precipitating and exacerbating factors, with or without aura, MIDAS and HIT-6 questionnaire.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For group 1: Normal healthy individual without migraine.
- •For group 2: Clinical history of migraine diagnosed by a neurologist according to the International Classification of Headache Disorders.
排除标准
- •Subjects with stenotic intracranial or extracranial arteries or intracranial abnormalities diagnosed with TCD.
结局指标
主要结局
contrast-enhanced transcranial Doppler
时间窗: 1 year
次要结局
- brain MRI(1 year)
研究者
Yingqi Xing
Director of Head and Neck Vascular Ultrasound Center
The First Hospital of Jilin University