Magnesium Versus High Dose Fentanyl in Attenuating Stress Response to Endotracheal Intubation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- heart rate values
研究概览
简要总结
this study is designed to assess the efficacy of MgSO4 versus high dose fentanyl compared to conventional anesthesia in attenuating stress response to intubation
详细描述
to assess the effect of MgSO4 combined with fentanyl compared to high dose fentanyl in attenuating stress response in cancer patients undergoing surgeries under general anesthesia requiring endotracheal intubation
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cancer patients undergoing surgery under general anesthesia requiring endotracheal intubation
排除标准
- •allergy to any of the used drugs
- •renal or hepatic impairment
- •hypertensive patients, patients with cardiovascular or cerebrovascular diseases
研究组 & 干预措施
Magnesium sulphate- Fentanyl
30 mg per kg MgSo4 infusion in 100 ml saline over 10 minutes
干预措施: Magnesium sulfate- Fentanyl (Drug)
Magnesium sulphate- Fentanyl
30 mg per kg MgSo4 infusion in 100 ml saline over 10 minutes
干预措施: Fentanyl 2Mcg/kg (Drug)
Fentanyl 4 mic
4 mic per kg fentanyl i.v
干预措施: Fentanyl 4Mcg/kg (Drug)
Fentanyl
2 mic per kg fentanyl i.v
干预措施: Fentanyl 2Mcg/kg (Drug)
Lidocaine- Fentanyl
Lidocaine 1.5 mg/kg
干预措施: Fentanyl 2Mcg/kg (Drug)
Lidocaine- Fentanyl
Lidocaine 1.5 mg/kg
干预措施: Lidocaine 1.5 mg/kg (Drug)
结局指标
主要结局
heart rate values
时间窗: 5 minutes
changes in heart rate values after intubation
次要结局
- coughing during intubation(lntubation time)
- blood pressure(5 minutes)
研究者
Walaa Youssef Elsabeeny
Lecturer of anesthesia and pain management
National Cancer Institute, Egypt