Lebanese Interhospital Pneumococcal Surveillance Program (LIPSP)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 700
- 试验地点
- 1
- 主要终点
- Serotype prevalence of S. pneumoniae in invasive pneumococcal disease
研究概览
简要总结
Streptococcus pneumoniae (pneumococcus) is a bacterium that causes severe infections in children and adults such as meningitis, pneumonia, and blood stream infection. There are many types of these bacteria defined by the type of sugar coat that they have. These are classified as serotypes. There are common serotypes that cause severe disease and are preventable by vaccination of children. Other less common types are more difficult to prevent. The investigators aim to determine the serotypes that cause invasive pneumococcal disease in Lebanon and to study their sensitivity to different antibiotics. The investigators will collect bacterial isolates from different hospitals in Lebanon isolated from the blood or spinal fluid of patients with invasive pneumococcal disease. This information will help the investigators determine the usefulness of available pneumococcal vaccines in preventing these infections. The data will be distributed to all primary care physicians treating children in Lebanon and will be shared with the Ministry of Health.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Day 至 —(Child, Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Samples included in the study are those that are:
- •culture proven
- •invasive pneumococcal infections
- •in patients of all ages admitted to different hospitals all over Lebanon
- •Acceptable samples include:
- •positive isolates from blood
- •cerebrospinal fluid
- •other normally sterile body sites such as empyema fluid, abscesses, joint fluid, middle ear fluid obtained by tympanocentesis in the operating room, and lung needle aspiration
排除标准
- •non S. pneumoniae isolates
结局指标
主要结局
Serotype prevalence of S. pneumoniae in invasive pneumococcal disease
时间窗: yearly
次要结局
- Determine the antibiotic sensitivity of S. pneumoniae and the association with specific serotypes(yearly)
研究者
Dr. Ghassan Dbaibo
Professor
American University of Beirut Medical Center
