Cognitive Training in Patients With Obsessive Compulsive Disorder
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 9
- 试验地点
- 2
- 主要终点
- Cambridge neuropsychological test automated battery (CANTAB)
研究概览
简要总结
This unique study will allow us to observe the neural correlates associated with working memory in an obsessive compulsive disorder (OCD) paradigm. We believe that developing working memory in participants suffering with OCD will reduce the severity of their symptomology. This will allow a greater understanding into the functioning of these participants which in turn presents with treatment possibilities.
详细描述
It is currently unclear whether cognitive training using a working memory task, is effective in reducing obsessive-compulsive symptoms and neuropsychological deficits in patients with OCD. Two groups (OCD and control) will be recruited. Both groups will undergo an intervention consisting of 8 weeks of cognitive training. Working memory, neuropsychological functioning and OCD symptomatology will be assessed pre and post-treatment, in both groups. Furthermore neuroimaging using functional magnetic resonance imaging (fMRI) will be conducted at baseline as well as at the end of the 8 week period in both groups. The scan will serve to show any structural or functional changes in the frontostriatal area involved with working memory. To our knowledge, this is one of the first studies to date to examine whether cognitive training improves symptoms in OCD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •A primary diagnosis of OCD, with a score > 16 on the Yale-Brown Obsessive Compulsive Scale (YBOCS) (Goodman et al, 1989b, 1006-1011).
- •Participants must be aged older than 18 and younger than 65 years.
- •Right handed.
- •If taking SSRI's the participant needs to be on a stable dose for at least 2 months.
排除标准
- •Significant physical or neurological illnesses. An exception will be made for patients taking SSRI's (and not using any other drugs).
- •Any significant current DSM disorder (in addition to OCD).
- •Past history of significant substance or alcohol abuse.
- •Pregnancy.
- •Any metal pins/ prostheses or cardiac pacemakers.
- •Sufferers of claustrophobia.
- •Head injury
结局指标
主要结局
Cambridge neuropsychological test automated battery (CANTAB)
时间窗: Immediately after intervention
Yale-Brown Obsessive Compulsive Scale (YBOCS)
时间窗: Immediately after intervention
次要结局
未报告次要终点
研究者
Christine Lochner
Professor Christine Lochner
University of Stellenbosch