Effect of intravenous anaesthetics versus inhalational anaesthetics on delayed cerebral ischemia following aneurysmal sah: a randomised clinical trial (IVIA-DAS)
试验速览
- 阶段
- 3 期
- 状态
- 进行中（未招募）
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- To compare the incidence of delayed cerebral ischemia in patients undergoing
研究概览
简要总结
This trial is designed to see the effect of anaesthesia drugs on the incidence of delayed cerebral ischemia in patients of aneurysmal subarachnoid haemorrhage undergoing surgical clipping of the neck of aneurysm. after randomly dividing into two groups, patients of one group will receive propofol( intravenous) as an anaesthetic agent, while the other will receive sevoflurane ( inhalational) as the anaesthetic agent. Postoperatively these patients are followed up to compare the incidence of Delayed cerebral ischemia between the two groups. Secondarily we reach CSF levels of the eNOS enzyme, collected at the time of surgery. we also check neurological outcomes using MRS scoring at discharge and both MRS and GOSE scale at 1 month and w3 months.w
研究设计
- 研究类型
- Interventional
- 分配方式
- Random Number Table
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Ruptured aneurysm posted for Surgical Clipping WFNS grade 1,2,3 Anterior circulation aneurysm.
排除标准
- •Postictal day 4 or more Postoperative neurological deterioration due to surgical or systemic causes Hydrocephalus.
结局指标
主要结局
To compare the incidence of delayed cerebral ischemia in patients undergoing
时间窗: starting after the surgery till the discharge from hospital
to propofol.
时间窗: starting after the surgery till the discharge from hospital
clipping of aneurysm surgery under general anesthesia with sevoflurane when compared
时间窗: starting after the surgery till the discharge from hospital
次要结局
- Estimation of CSF eNOS levels(intraoperative ( during aneurysm Clipping surgery))
- Neurological outcome at discharge ( MRS score)(at discharge)
- Neurological outcome at 3 months post surgery(GOSE, MRS score)(1 months after surgery, 3 months after surgery)