Effect of Acute Nitrate Supplementation on Vascular Function in Hispanic, Black and White Population
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Forearm blood flow
研究概览
简要总结
The purpose of the study is to assess vascular function in African Americans, Hispanic and Caucasian Americans to better understand racial differences in cardiovascular health. The investigators will further investigate the affect of Beetroot juice on the vascular function of all participants.
详细描述
African Americans and Hispanic individuals have the highest incidence of type 2 diabetes, which increases their risk of all cardiovascular diseases. One of the hallmarks of type 2 diabetes is vascular dysfunction, caused by a lack of nitric oxide bioavailability. Vascular function and blood flow responses to exercise have been shown to improve after nitrate supplementation (beetroot juice), However, whether nitrate supplementation will improve vascular function in African American and Hispanic individuals remains unknown. The investigators will perform a randomized, placebo-controlled study in healthy African American, Hispanic and Caucasian subjects. They will be studied before and 90 minutes after consuming Beetroot juice (high nitrate supplement) or Placebo, with at least 1-week washout period between the two visits (Kenjale AA et al., J Appl Physiol 2011).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
it will be double blinded
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women who are either Caucasian American, Hispanic, or non-Hispanic African American
排除标准
- •Blood pressure higher than or equal to 140/90 mmHg
- •BMI > 35kg/m2
- •Have a history of cardiovascular, neurological or vascular diseases
- •Take prescription medications
- •Are smokers
- •Are pregnant
研究组 & 干预措施
Beetroot Juice
140 ml of beetroot juice (high nitrate dietary supplement)
干预措施: Beetroot juice (Dietary Supplement)
Placebo
Placebo drink looks and tastes like the beetroot juice but has the nitrate removed from the juice.
干预措施: Placebo drink (Dietary Supplement)
结局指标
主要结局
Forearm blood flow
时间窗: through study completion, an average of 2 year
Blood flow of the brachial artery will be measured continuously at rest, during 3 min of handgrip exercise and for up to 1 min after the cessation of handgrip exercise.
次要结局
- Flow mediated vasodilation(through study completion, an average of 2 year)