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临床试验/NCT05799430
NCT05799430招募中不适用

Effects of Interdisciplinary Medication Review in Chronic Complex Patients or Patients With Polypharmacy After Hospital Discharge

Fundación Pública Andaluza para la gestión de la Investigación en Sevilla1 个研究点 分布在 1 个国家目标入组 372 人开始时间: 2023年4月15日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
372
试验地点
1
主要终点
Number of hospitalization episodes

研究概览

简要总结

The goal of this prospective multicentre clustered randomized controlled trial is to evaluate the effect on new hospitalization episodes of a multidisciplinary medication review in primary care patients with polypharmacy or chronic complex conditions after hospital discharge.

The multidisciplinary team will be integrated by a family physician (FP), a primary care nurse (PCN) and a primary care pharmacist (PCP). Patient will be adults aged 65 years and older. Polypharmacy refers to the use of 10 or more drugs based on information in electronic prescription software.

Research questions are:

In elderly patients with polypharmacy, which is the effect of an interdisciplinary medication review after hospital discharge in comparison with standard care, in terms of:

  • new hospitalization episodes?
  • number of drugs prescribed?
  • prescribed drugs adequacy?

详细描述

Centres will be randomized to medication review intervention or usual care group. Eligible patients will be ask for informed consent. For patients in the intervention group, PCP will collect information about prescribed medication and diseases from the electronic health record and e-prescribing application. The medication review in primary care will be focus to reconcile the medications the patient was taking prior to admission and those initiated in hospital, with the medications they should be taking post-discharge to ensure all changes are intentional and that discrepancies are resolved as soon as possible. The review process will include detection of potential drugs interactions, wrong doses, lack of adherence (based on dispensing recorded data) and adequacy to explicit criteria for potentially inappropriate prescriptions included in different tools: a) STOPP-STAR, STOPP-Pal, LESS-CHRON lists; b) Guideline for Medication Review in Primary Care, a local publication and c) Medication review in patients with polypharmacy. A list of drugs frequently associate with potentially inappropriate prescriptions. Andalusian health Service). PCP will write a report to communicate the results of medication review to primary care physician and nurse. The multidisciplinary team will define a personalized therapeutic plan to be implemented for every patient.

Patients in the control group will receive usual care.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Health Services Research
盲法
Single (Outcomes Assessor)

入排标准

年龄范围
65 Years 至 —(Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Hospital discharge in the last 48 h and one of the following conditions:
  • •Polypharmacy: ten o more drugs prescribed in a chronic schedule OR
  • •Complez Chronic Condition

排除标准

  • •Patients in last days of life
  • •Major mental health disorder
  • •Patient on dialysis
  • •Organ transplant patients

研究组 & 干预措施

Intervention

Experimental

The intervention group will receive a multidisciplinary medication review and a personalized therapeutic plan in the following 72 hours after hospital discharge. The intervention will be developed by a multidisciplinary team that includes a family physician (FP), a primary care nurse (PCN) and a primary care pharmacist (PCP). PCP is a pharmacist working in a full-time base for the Pharmacy Service in a Primary Care District in Andalusian Public Health Service.

干预措施: Multidisciplinary medication review (Behavioral)

Control group

Active Comparator

The control group will receive usual care.

干预措施: Control group (Behavioral)

结局指标

主要结局

Number of hospitalization episodes

时间窗: 12 months

Registered in Electronic Health Record. In emergency department or in hospital service

Length of Hospital Stay

时间窗: 12 months

Registered in Electronic Health Record.

次要结局

  • Healthcare utilisation(12 months)
  • Mortality(12 month)
  • Number of medications(12 months)
  • Number of proposal about treatment improvement agreed with primary care team(7 days)
  • Number of potentially inappropriate drugs(12 months)
  • Number of proposal about treatment improvement(7 days)
  • Number of proposal about treatment improvement accepted by the patient or care(7 days)

研究者

研究点 (1)

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