NL-OMON47057已完成不适用
Deep Brain Stimulation in Patients with Chronic Treatment Refractory Anorexia Nervosa: a Pilot Study - DBS in Anorexia Nervosa
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 4
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Inclusion criteria studypopulation:
- •Primary diagnosis: Anorexia Nervosa (restricting or purging type; 307.1) according to the DSM-IV criteria based on a psychiatric interview
- •Chronicity, defined by an illness duration > 10 years
- •Disabling severity with substantial functional impairment according to the DSM-IV criterion C and a Global Assessment of Function (GAF) score of 45 or less for at least two years
- •Treatment refractoriness, defined as lack of response to two or more typical modes of treatment , including one hospital admission or inpatient treatment in a specialized clinic, as described in the Multidisciplinaire Richtlijn Eetstoornissen (Trimbosinstituut 2008).
- •BMI < 15 (level of severity acoording to the DSM 5: extreme)
- •Age: 25-65 years old
- •Written informed consent
- •Dutch or English speaking and able to answer the study questions
- •Able to fully understand the consequences of the procedure
- •Capable to make his or her own choice without coercion ;Inclusion criteria healthy controlgroup EEG-substudy:
- •2. 25-50 years
- •3. Matched intelligence level (NLV/DART)
- •4. Healthy BMI (18.5-25)
排除标准
- •Exclusion criteria studypopulation:
- •Unstable physical condition (severe electrolyte disturbances, cardiac failure, other physical contraindications for surgery/anesthesia). The use of anticoagulants must be able to be stopped before surgery
- •Treatable underlying cause of anorexia/underweight
- •Active neurological disease like Parkinson*s disease, dementia, epilepsy
- •Schizophrenia/history of psychosis, bipolar disorder
- •Alcohol or substance abuse (including benzodiazepines) during last 6 months
- •Current Tic disorder
- •Antisocial personality disorder
- •Standard MRI scan exclusion criteria (pregnancy, pacemaker and metals contraindicated for MRI);Exclusion criteria healthy control group EEG-substudy:
- •1. (History of) eating disorders
- •2. (History of) psychiatric disorders
- •3. Relevant somatic/neurological disorders
- •4. Use of psychoactive drugs/substances
研究者
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