NCT02798679已完成不适用
Cardiac Fibrosis and Risk Prediction in Cancer Treatment-Related Cardiotoxicity
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Cardiotoxicity assessed clinically or by cardiac MRI
研究概览
简要总结
The purpose of this study is to determine whether pre-existing cardiac fibrosis is a predictor of cancer treatment-related cardiotoxicity.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Stage I-III breast cancer or lymphoma with a >2 year life expectancy
- •A treatment plan that includes anthracyclines and/or trastuzumab
- •Age >45 years
- •Able to hold breath for 10 seconds
- •Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
排除标准
- •Refusal or inability to provide informed consent
- •Known heart failure or LVEF <50%
- •Heart rate over 100 bpm
- •Renal dysfunction with GFR <30 mL/min/1.73m2
- •Participants with pacemakers, defibrillators, functioning neurostimulator devices or other implanted electronic devices
- •Symptomatic claustrophobia
- •Plans to move within 24 months of enrollment
结局指标
主要结局
Cardiotoxicity assessed clinically or by cardiac MRI
时间窗: 24 months
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
招募中
不适用
The Prognostic Significance of Fibrosis Detection in CardiomyopathyCoronary Artery DiseaseCardiomyopathyNCT00930735Royal Brompton & Harefield NHS Foundation Trust3,000
招募中
不适用
Predictive Properties of Myocardial Fibrosis Biomarkers on the Outcome of Atrial Fibrillation AblationWomen and Men Over 18 Years OldAF Ablation (ECS recommendation2020&ACS2014) Either for Paroxysmal AF Unresponsive to Anti-arrhythmic Treatment Either for Persisting Symptomatic AFAble to Give His Non Opposition to Participate to the StudyNCT05179902University Hospital, Clermont-Ferrand190
已完成
不适用
Fibrosis in Chronic and Delayed Myocardial InfarctionChemotherapy Induced Systolic DysfunctionCarcinoid SyndromeAortic StenosisNCT05756608University of Edinburgh50
已完成
不适用
Prognostic Value of Myocardial Fibrosis Quantified Using CMR in Patient With Dilated CardiomyopathyCardiomyopathy, DilatedNCT02352129Assistance Publique Hopitaux De Marseille262
已完成
不适用
Inflammation, Fibrosis and Risk of Recurrence After Atrial Fibrillation AblationAtrial InflammationAtrial FibrillationNCT03757741Cardio Med Medical Center100