Preoperative Statin Use and Major Adverse Cardiovascular Events in Liver Transplant Recipients: A Multicenter Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9,000
- 试验地点
- 1
- 主要终点
- 30-day Major Adverse Cardiovascular Events
研究概览
简要总结
The goal of this multicenter observational study is to determine whether preoperative statin use reduces major adverse cardiovascular events or other complications after liver transplantation. The main question it aims to answer is:
Does preoperative statin use reduce major adverse cardiovascular events or other complications after liver transplantation? The records of participants who already took statins before liver transplantation will be reviewed.
详细描述
Cardiovascular complications have emerged as a leading cause of early postoperative death following liver transplantation (LT), accounting for over 40% of early deaths. As a result, preventing postoperative cardiac complications has become a critical concern in the management of LT recipients.
Statin therapy has been suggested to improve perioperative and long-term outcomes in various surgical populations, primarily through LDL cholesterol reduction as well as pleiotropic effects, such as enhanced endothelial function and anti-inflammatory actions. However, evidence specifically examining the impact of preoperative statin therapy on cardiovascular outcomes after LT remains limited, highlighting the need for further research in this population.
This study aimed to address the current knowledge gap by investigating the association between preoperative statin use and the incidence of major adverse cardiovascular events within 30 days after liver transplantation in liver transplant recipients. Secondary outcomes included overall mortality, early allograft dysfunction, acute kidney injury, length of stay in the intensive care unit, duration of mechanical ventilation, and myocardial injury after non-cardiac surgery within 3 and 30 days after transplantation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •- Adult patients aged ≥18 years who underwent liver transplantation
排除标准
- •Patients who underwent liver re-transplantation
- •Patients with preoperative acute-on-chronic liver failure (ACLF)
- •Patients with preoperative fulminant hepatic failure
研究组 & 干预措施
Statin group
Patients who received preoperative statin therapy
干预措施: Preoperative Statin Use (Drug)
Control group
Patients who did not receive preoperative statin therapy
结局指标
主要结局
30-day Major Adverse Cardiovascular Events
时间窗: 30 days after liver transplantation
The composite of cardiovascular death, heart failure, myocardial infarction, atrial fibrillation, ventricular arrhythmia, ischemic electrocardiogram changes (ST-segment depression or elevation) with chest tightness, pulmonary embolism, and stroke
次要结局
- Myocardial Injury after Non-Cardiac Surgery (MINS)(Within 3 days and 30 days after liver transplantation)
- Acute Kidney Injury(Within 7 days after liver transplantation)
- Overall Mortality(From the date of liver transplantation to May 19, 2025)
- Early Allograft Dysfunction(Within 7 days after liver transplantation)
- Intensive Care Unit Length of Stay(From the date of liver transplantation until intensive care unit discharge, up to 600 days)
- Mechanical Ventilation Duration(From the date of transplantation until discontinuation of mechanical ventilation, up to 600 days)
研究者
Jun-Gol Song
Professor
Asan Medical Center