MOLECULAR BIOMARKERS IN DELIRIUM AND DEMENTIA
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 700
- 试验地点
- 1
- 主要终点
- Delirium
研究概览
简要总结
The current project aims to measure biomarkers in the cerebrospinalfluid (CSF) and serum samples from patients with delirium. We hope to uncover new insights into the pathophysiology of delirium and explore its link to dementia.
详细描述
Delirium is a common and serious complication to acute illness, and is characterized by acute disturbances in attention, awareness, and cognition. Dementia is a major risk factor of delirium, and delirium increases the risk of dementia progression and development. As the conditions share both clinical and epidemiological features, some researchers suggest that also pathophysiological links are shared. Understanding delirium pathophysiology, which is poorly understood, may thus help elucidate early molecular mechanisms in dementia.
This study aims to to increase our understanding of the pathophysiology of delirium and molecular links between delirium and dementia, by exploring cerebrospinal fluid (CSF) biomarkers.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with acute hip fracture
排除标准
- •Moribund patients.
- •Lack of consent
结局指标
主要结局
Delirium
时间窗: Daily during hospital stay (pre-/and postoperatively) until 5 days after surgery (or discharge)
Pre- and postoperative delirium
次要结局
- Dementia(Cognitive changes the first 48 months after inclusion)
研究者
Leiv Otto Watne
Postdoctoral Research Fellow
Oslo University Hospital