Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 61,292
- 试验地点
- 1
- 主要终点
- Hospital diagnoses
研究概览
简要总结
In this retrospective register study, clinically classified individuals with neurodegenerative disease from the years 2010-2021 will be verified from the clinical records from KUH and Oulu University Hospital (OUH). Based on the Finnish social security number, these individuals will be linked to the the national registers of Statistics Finland and Finnish Social and Health Data Permit Authority Findata including incomes, sociodemographic factors, education, occupation, criminal records as well as to the national registers including the bought pharmaceuticals, comorbidities and causes of death. For each study case, 10 randomly selected control cases, matched with age, sex and geographical area, will be used.
The aim of the study is to examine:
- 1) The prevalence of criminal and other disruptive behaviour in groups of different neurodegenerative diseases prior to and after the diagnosis
- 2) Changes in employment, residency,income, and marital status prior to and after the neurodegenerative disease diagnosis
- 3) Hospital diagnoses and reimbursable drugs prior to and after the diagnosis
- 4) Causes of death in patients with neurodegenerative disease to study excess mortality of the patients
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The diagnosis of neurodegenerative disease (ICD-10) in KUH or OUH between the years 2010-2021
- •Age, sex and residency matched controls (Every research patient has 10 controls matched by age, gender, and place of residency)
排除标准
- •Patients will be divided into different diagnostic groups based on the accepted diagnostic criteria in use. If some of the formed groups contain less than 5 subjects, the disease group in question is excluded from the analyses in order to ensure the privacy protection of the subjects
研究组 & 干预措施
Patients with neurodegenerative disease
Patient diagnosed with neurodegenerative disease (ICD-10 diagnosis code) between 2010-2021
Matched controls
Age, gender, and place of residency matched for those of a patient that was alive at the end of the year of the diagnosis
结局指标
主要结局
Hospital diagnoses
时间窗: 1994-2021
Hospital diagnoses from the National Discharge Register. The National Discharge Register contains information of all hospitalizations after 1969, including ICD-8, ICD-9, and ICD-10 classifications to detect comorbidities of the patients. Two registers, "Terveydenhuollon hoitoilmoitusrekisteri (Hilmo)" and "Perusterveydenhuollon avohoidon hoitoilmoitus (Avohilmo)" of the Finnish Institute for Health and Welfare are used.
Socio-demographic data
时间窗: 1987-2021
Employment, residency, Income, Marital status. Socio-demographic outcome data is extracted from Statistics Finland, FOLK Basic data module. Possible changes in employment and residency are examined, and mortality and emigration will be considered as censoring factors
Causes of death
时间窗: 2010-2021
Causes of death from Statistics Finland. Statistics Finland maintains a registry of causes of death and death certificates, which are supplemented with data from the population information system of the Population Register Centre. Registry data are used to study excess mortality of the patients.
Criminal behaviour: Type of offence, time of offence and other disruptive behaviour
时间窗: 1996-2020
Statistics Finland, Statistics on offences and coercive measures. Criminal behaviour is investigated utilising the reports of offences received by the police. The classification of offences is based on the three- or six-numbered offence classification by Statistics Finland, which enables the examination of different offences including e.g., violence, property, and traffic offences. The data extracted from the register include the type of the offence and time. Also, other disruptive behaviour based on the captures performed by the police (e.g., captures of intoxicated persons) is extracted.
Medication use
时间窗: 1995-2021
Reimbursable drugs from the Social Insurance Institution of Finland (SII). Finnish residents are covered under the National Health Insurance (NHI) scheme run by the SII. SII maintains a nationwide registry of all patients, with dispensed reimbursable drugs 1995-, including opioids and neuropathic pain medications. Data of medication use, cost, and reimbursement data are gathered from the SII database.
次要结局
未报告次要终点