NCT00463281已完成不适用
Observational Study of Multimodal CT in Acute Ischemic Stroke to Define a Tissue Window for Thrombolysis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- modified Rankin Scale scores 0-2
研究概览
简要总结
Aim of this study is to define a CT-based "tissue window" for stroke thrombolysis. Our primary hypothesis is that
- patients with a "tissue window" (favourable non-contrast CT (NCCT) scan and an intracranial occlusion on CT angiography (CTA) or perfusion-CT-mismatch" (area of reduced cerebral blood flow (CBF) > area of reduced cerebral blood volume (CBV)) represent a significant proportion (> 20%)of acute stroke patients and therefore are an important target group for future interventional studies
- patients with a "tissue window" suffer an unfavourable outcome (> 50 % mRS =>4 at 3 months)if the occluded artery was not recanalized.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ischemic anterior circulation stroke
- •last seen normal < 12 hours
- •stroke severity => 3 on the National Institute of Health Stroke Scale
- •multimodal CT stroke protocol performed
- •informed consent obtained
排除标准
- •premorbid modified Rankin Scale score > 3
- •contraindications to contrast media application
- •pregnancy or breast feeding
- •subacute stroke > 50 % of MCA territory
- •CT evidence of non-vascular cause of stroke symptoms
结局指标
主要结局
modified Rankin Scale scores 0-2
时间窗: 90 days
次要结局
未报告次要终点
研究者
研究点 (1)
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