Feasibility and Efficacy of a High-Intensity Exercise Intervention in Elderly Healthy Controls
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 4
- 试验地点
- 1
- 主要终点
- Heart Rate
研究概览
简要总结
The goal of this interventional study was to test the high-intensity interval training called Aphasia Physical Exercise (APEX) in healthy older adults. The main questions it aimed to answer were:
- what is the safety and feasibility of APEX?
- what are APEX's acute physiological effects?
- what is APEX's effects on functional fitness?
- what is APEX's effects on cognition?
Participants underwent:
- Baseline testing session (#1) with cognitive measures only (a week before the Pre-exercise session);
- Pre-exercise session (#2) with maximum oxygen consumption and heart rate assessment, functional fitness and cognitive measures (3-7 days before the start of the exercise program);
- APEX program, two APEX classes per week for four weeks (eight classes in total);
- Post-exercise session (#3), functional fitness and cognitive measures, (0-2 days after the end of the exercise program).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between the ages of 50 and 80
- •Ambulatory and community-dwelling
- •Able to travel to University of San Francisco for weekly exercise classes
- •No serious underlying health or neurological conditions
排除标准
- •Inability to complete physical function assessment or inability to do a chair stand without using hands
- •Use of antidiabetic medications
- •Use of testosterone supplement or replacement
- •Clinical disorder precluding/interfering with participation or assessments (identified by Physical Activity Readiness Questionnaire (PAR-Q+)), including: unstable angina, arrhythmia, uncontrolled hypertension, end stage renal disease on hemodialysis, lower extremity amputation or paralysis, neurological conditions causing functional or pronounced cognitive impairments, active malignancy except for non-melanomatous skin cancers
- •Previous neurological history such as stroke, traumatic brain injury, multiple sclerosis, long-term pre-stroke seizures, Parkinson's, Alzheimer's, etc.
- •Unable to provide consent
研究组 & 干预措施
APEX
Physical exercise intervention based on high-intensity interval training
干预措施: APEX (Behavioral)
结局指标
主要结局
Heart Rate
时间窗: 4 weeks during intervention
Heart rate measured in beats per minute.
Flanker Task Accuracy
时间窗: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
Number of correct trials.
Number of Repetitions in 30-Second Chair Stand Test
时间窗: Once 3-7 days before start of intervention and once 0-2 days after end of intervention
The number of sit-to-stands completed in 30 seconds on a standard 17" seat-height chair with arms folded across the chest.
Visual Search Task Reaction Time
时间窗: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
Reaction time on correct trials in seconds
Forward Digit Span
时间窗: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
The length of the longest sequence of random digits that a participant can correctly recall twice.
Functional Reach Test Distance
时间窗: Once 3-7 days before start of intervention and once 0-2 days after end of intervention
The distance in inches of an individual's forward reach with one arm while maintaining a standing position with feet flat on the floor at hip width.
Attendance Rate
时间窗: 4 weeks during intervention
The number of classes attended out of eight total classes.
Timed Up-And-Go Time
时间窗: Once 3-7 days before start of intervention and once 0-2 days after end of intervention
The number of seconds for an individual to rise from a seated position, walk eight feet, turn around, and return to a seated position.
Number of Steps in 2-minute Step Test
时间窗: Once 3-7 days before start of intervention and once 0-2 days after end of intervention
The number of right knee raises completed in two minutes while marching in place and raising each knee to a point midway between the patella (kneecap) and iliac crest (top hip bone).
Forward Spatial Span
时间窗: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
The length of the longest sequence of random positions that a participant can correctly recall.
Backward Spatial Span
时间窗: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
The length of the longest sequence of random positions that a participant can correctly report backward.
Go/No-Go Task Hits
时间窗: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
Hits are the proportion of correct responses on trials when "go" is presented.
Flanker Task Reaction Times
时间窗: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
Reaction time on correct trials in seconds.
Stroop Task Accuracy
时间窗: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
Number of correct trials.
Stroop Task Reaction Times
时间窗: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
Reaction time on correct trials in seconds.
Visual Search Task Accuracy
时间窗: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
Number of correct trials
Backward Digit Span
时间窗: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
The length of the longest sequence of random digits that a participant can correctly report backward twice.
Go/No-Go Task Reaction Times
时间窗: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
Reaction times are for hit trials only (correct responses when "go" is presented) in seconds.
次要结局
未报告次要终点
研究者
Maria Ivanova
Research Scientist
University of California, Berkeley