Nitric Oxide Bioavailability and Dynamics of Blood Flow and Vasodilation With Age
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Change in Skeletal Muscle Blood Flow within the Leg via Doppler Ultrasound
研究概览
简要总结
The main purpose of this study is to evaluate the effects of an acute dose of dietary nitrate in the form of beetroot juice on skeletal muscle blood flow in response to dynamic knee extension exercise in healthy older adults. All subjects will receive active (rich in dietary nitrate) or placebo (devoid of nitrate) supplementation.
详细描述
Dietary nitrate (beetroot juice) is reduced to nitrite and nitric oxide within the digestive system of humans. Nitric oxide exerts potent vasodilator effects, which have been shown to reduce blood pressure and enhance exercise economy in humans. This pressure reducing effect may have implications within the regulation of blood flow during dynamic exercise in older adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy older adults 60-80 years of age
排除标准
- •Hypertension,
- •Heart disease,
- •Diabetes,
- •Body mass index (BMI) ≥ 30 kg/m2,
- •Autonomic disorders and other conditions that may alter blood pressure or vascular function
- •Medications that might normally alter blood pressure or vascular function.
- •Older women taking hormone replacement therapy medications.
研究组 & 干预措施
Nitrate Rich Beetroot Powder (nitrate)
Dietary nitrate in the form of beetroot powder (10g) mixed in water will be administered acutely
干预措施: Super Beets (Dietary Supplement)
Nitrate Rich Beetroot Powder (nitrate)
Dietary nitrate in the form of beetroot powder (10g) mixed in water will be administered acutely
干预措施: Beetroot powder (Dietary Supplement)
Placebo Beetroot Powder
Beetroot powder devoid of nitrate (10g) will be mixed in water and administered acutely
干预措施: Super Beets (Dietary Supplement)
Placebo Beetroot Powder
Beetroot powder devoid of nitrate (10g) will be mixed in water and administered acutely
干预措施: Beetroot powder (Dietary Supplement)
结局指标
主要结局
Change in Skeletal Muscle Blood Flow within the Leg via Doppler Ultrasound
时间窗: Pre and 2 hours post acute ingestion of dietary nitrate and placebo with at least 5 days of separation between visits.
Leg blood flow via Doppler ultrasound examined during dynamic knee extension exercise. Change in blood flow in response to dynamic knee exercise will be measured to examine the influence of dietary nitrate.
次要结局
未报告次要终点
研究者
Darren P Casey
Assistant Professor
University of Iowa