NCT07325175招募中不适用
Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Longitudinal change in Motor Network Aperiodic Activity
研究概览
简要总结
The goal of this study is to understand the development and progression of childhood dystonia, a movement disorder, in children. The main questions it aims to answer are:
How does the activity of the neural network evolve in children with dystonia in the context of motor development? What are the effects of chronic and active stimulation on cortical and subcortical motor network function in children with deep brain stimulation (DBS)?
Participants will:
- Undergo noninvasive electrophysiological measurements (EEG, EMG) to quantify neural network activity. They will be tested at rest and during a simple motor reaction task.
- Children with DBS will be assessed in the on and off DBS state to assess effects of chronic and active changes in motor network function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 6 Years 至 21 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For dystonia subjects:
- •Dx of dystonia (with and without DBS)
- •willingness and ability to complete study protocols.
- •For Typically Developing Controls:
- •normal developmental milestones
- •absence of any neuropsychiatric disorder
- •no significant medical condition.
排除标准
- •history of epilepsy
- •presence of implanted medical devices (except DBS in dystonia subjects)
- •lack of cognitive or physical ability to complete study protocol.
研究组 & 干预措施
DBS
Experimental
Patients with DBS will complete neurophysiological recordings with DBS on and off
干预措施: DBS (Device)
结局指标
主要结局
Longitudinal change in Motor Network Aperiodic Activity
时间窗: -Baseline -Through study completion, an average of 2 years
次要结局
- Longitudinal change in Motor Network EEG connectivity(-Baseline -Through study completion, an average of 2 years)
- Longitudinal change in Motor Network Periodic Activity(-Baseline -Through study completion, an average of 2 years)
研究者
Travis Larsh
Assistant Professor
Children's Hospital Medical Center, Cincinnati
研究点 (1)
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