Recombinant Human Bone Morphogenetic Protein-2 In Absorbable Sponge Vs Platelet Rich Fibrin (PRF) In Grade Ii Furcation Defects - A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- BONE FILL
研究概览
简要总结
The present study evaluated clinically and radiographically the regenerative potential of rhBMP-2 in absorbable sponge and PRF in Grade II furcation.
详细描述
44 subjects were enrolled in the study. PPD, CAL, plaque index and gingival index were recorded and the evaluation of bone fill was performed after 6 months by using ImageJ® software. After 6 months, the bone fill obtained with rhBMP-2 was higher when compared to PRF. From this trial conducted over a period of 6 months, the unique properties associated with rhBMP-2 in absorbable sponge makes it a potential agent to be used as a graft material for Grade II furcation defects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
participant and outcome assessor are masked from the study
入排标准
- 年龄范围
- 20 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Systemically healthy male and female patients of age group 20-55 yrs
- •grade II furcation involvement and probing pocket depth of ≥5mm
排除标准
- •Medically compromised patients
- •subjects who underwent radiotherapy or chemotherapy in the past 12 months
- •patients having uncontrolled periodontal disease and
- •subjects smoking ≥10 cigarettes per day were excluded
研究组 & 干预措施
RhBMP-2
RhBMP-2 belongs to TGF-β super family with osteoinductive property which is capable of promoting bone formation
干预措施: RhBMP-2 absorbable sponge in grade II furcation (Drug)
PLATELET RICH FIBRIN
Platelet rich fibrin(PRF) is a healing biomaterial with a great potential for bone and soft tissue regeneration, without any inflammatory reactions
干预措施: PLATELET RICH FIBRIN in grade II furcation (Procedure)
结局指标
主要结局
BONE FILL
时间窗: 6 MONTHS
The evaluation of bone fill was performed after 6 months by using ImageJ® software.
次要结局
未报告次要终点
研究者
Dr R Viswa Chandra
Principal Investigator
SVS Institute of Dental Sciences