The Effects of Losartan and Spironolactone on Residual Renal Function Preservation in Peritoneal Dialysis Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 96
- 主要终点
- residual renal function of peritoneal dialysis patients
研究概览
简要总结
Aldosterone blockade is useful in preserving residual renal function in patients on PD.The long term efficacy of dual blockade of the RAAS is better than monotherapy.
详细描述
Residual renal function has been proven to contribute to improved survival and quality of life of dialysis patients. It is now recognized as an important factor in the prognosis of PD.The RAAS system is involved in the development of renal diseases. Angiotensin II and aldosterone are vital in this process. The beneficial effect of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker on residual renal function has been demonstrated in peritoneal dialysis patients. Unfortunately, neither ACE inhibition nor angiotensin receptor blocker fully supprsses aldosterone production. Now much focus has been placed on aldosterone antagonist.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who having been on PD continuously for one month, urine volume>600 ml/d, residual renal function>2ml/min/1.73m2, blood pressure>120/70mmHg, serum potassium levels<5.5mmol/l, stable clinical condition.
排除标准
- •Patients with infectious systemic disease, peritonitis during the preceding 1 month, who had taken ACEI/ARBs in the 3 preceding months, spirolactone in the 2 preceding weeks, intolerance to ACEI/ARBs, CHF, MI, malignant hypertension and stroke within the preceding 6 months.
研究组 & 干预措施
Losartan
Losartan is taken orally 100mg/d
干预措施: Losartan (Drug)
spirolactone
spirolactone is taken orally 20mg/d
干预措施: spirolactone (Drug)
losartan in combination with spirolactone
Losartan is taken orally 100mg/d and spirolactone is taken orally 20mg/d
干预措施: Losartan (Drug)
losartan in combination with spirolactone
Losartan is taken orally 100mg/d and spirolactone is taken orally 20mg/d
干预措施: spirolactone (Drug)
blank control
patients with antihypertensives besides ACEI/ARBs and spirolactone.
干预措施: blank control (Other)
结局指标
主要结局
residual renal function of peritoneal dialysis patients
时间窗: From date of randomization until the date of dropping out of the study or death from any cause, whichever came first, assessed up to 12 months.
次要结局
- peritoneal membrane function(From date of randomization until the date of dropping out of the study or death from any cause, whichever came first, assessed up to 12 months.)
研究者
Hong Liu
deputy director of nephrology department
Second Xiangya Hospital of Central South University