NCT02871856进行中（未招募）不适用
International Lung Screen Trial
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 2,000
- 试验地点
- 12
- 主要终点
- Change in quality of life
研究概览
简要总结
People who may be at increased risk of lung cancer due to age and smoking history will be invited to participate in this international study to determine the best way of using computed tomography (CT) of the chest to screen for early lung cancer. Overseas data show that CT screening (screening tests can find diseases early, when they're easier to treat) can reduce deaths from lung cancer and this study will help determine who is most likely benefit from screening.
详细描述
[insert site name]
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 55 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Women or men age from 55 to
- •Current or former smokers. A former smoker is defined as one who has stopped smoking for one or more years.
- •An estimated 6-year lung cancer risk of ≥1.51% based on the PLCOm2012 risk prediction model or ≥ 30 pack-years smoking history (pack-year is defined as number of pack of cigarettes smoked per day multiply by the number of years smoked. If a participant stopped smoking for 6 months or more and then restarted smoking again, the time will be subtracted from the total duration of smoking in 0.5 year increments)
- •ECOG performance status 0 or
- •Capable of providing, informed consent for screening procedures (low dose spiral CT)
- •Exclusion Criteria
- •Clinical symptoms suspicious for lung cancer e.g. hemoptysis, chest pain, weight loss
- •Any medical condition, such as severe heart disease (e.g. unstable angina, chronic congestive heart failure), acute or chronic respiratory failure, home oxygen therapy, bleeding disorder, that in the opinion of the investigator could jeopardize the subject's safety during participation in the study or unlikely to benefit from screening due to shortened life-expectancy from the co-morbidities
- •Have been previously diagnosed with lung cancer
- •Have had other non-curatively treated cancer outside the lung.
- •Pregnancy
- •Pneumonia or bronchitis requiring antibiotic treatment within the last 12 weeks
- •Unwilling to have a spiral chest CT
- •Chest CT within 2 years
- •Does not fit into CT scanner table due to gross obesity
- •Cannot lie on CT scanning table on the back with arms over the head
- •Received chemotherapy or cytotoxic drugs within the last 6 months
- •Unwilling to sign a consent
排除标准
- 未提供
结局指标
主要结局
Change in quality of life
时间窗: 5 Years
Number of nodules
时间窗: 5 years
The number of Lung cancers
时间窗: 5 years
次要结局
- Cancer detection rate(5 years)
- Types and number of investigations(5 Years)
研究者
Kwun Fong
Professor
The University of Queensland
研究点 (12)
Loading locations...
相似试验
已完成
不适用
Early Lung Cancer Detection Using Computed TomographyLung CancerNCT00188734University Health Network, Toronto5,000
Enrolling By Invitation
不适用
Implementation of Lung Cancer Screening in the First Line Zone of ZORA (Flanders), Using a Low Dose CT-scanLung Cancer, Nonsmall CellSmoking CessationLung Cancer, Small CellLung CancerNCT06293833University Hospital, Antwerp700
招募中
不适用
Screening for Lung Cancer in Subjects With Family History of Lung CancerLung CancerNCT05762731The University of Hong Kong1,520
已完成
不适用
Pilot Study of High Risk Lung Cancer ScreeningLung CancerNCT03683940University of Colorado, Denver48
招募中
不适用
Risk Factors for Postoperative Cough in Patients Undergoing Thoracoscopic Lung ResectionLung CancerNCT06476249Hematology department of the 920th hospital1,000