Changes in Glycopeptides of Serum Immunoglobulin G in Patients With Acute Myocardial Infarction and the Relationships Between Its Change and Prognosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Serum quantitative determination of lgG
研究概览
简要总结
The aim of this study is to investigate the changes in glycopeptides of serum immunoglobulin G in patients with acute myocardial infarction and the relationships between its change and prognosis.
详细描述
Immunoglobin G (IgG), a highly abundant glycoprotein in serum, is known to participate in blood immune responses.It has been an increasing interest in the analysis of the abnormal glycosylation of human lgG in healthy and disease states, such as autoimmune diseases and cancer.However, there is few relevant studies about the changes in glycopeptides of serum immunoglobulin G in patients with acute myocardial infarction. This study was performed for the frst timeto assess the quantitative changes of serum IgG glycosylation in patients with acute myocardial infarction and the relationships between its change and prognosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •diagnosed as STEMI.
- •with left ventricular ejection fraction（LVEF）>=45%
- •written informed consents are obtained
- •admitted within 24 hours after chest pain attacked
排除标准
- •complicated with rheumatic heart disease, coronary arteritis, hypertrophic cardiomyopathy or dilated cardiomyopathy
- •complicated with malignant tumor,the immune system diseases, blood system diseases, recently (within 2 weeks) taking glucocorticoid drugs, the use of immunosuppressive agents and cerebral infarction
- •with acute or chronic infection, surgery or trauma in the last month
- •secondary hypertension, severe liver dysfunction,severe renal insufficiency
- •with abnormal thyroid function or allergy to iodine agent refusal to sign the informed consent
结局指标
主要结局
Serum quantitative determination of lgG
时间窗: 12 months
Quantitative measurements the changes of serum IgG glycosylation by HPLC-MRM
次要结局
- MACEs during 12-month follow-up(12 months)
- The changes of LVEF in two groups(12 months)
- Relationship between the serum hs-CRP and the quantitative level of lgG glycopeptides in peripheral blood.(12 months)