跳至主要内容
临床试验/CTRI/2025/12/098349
CTRI/2025/12/098349尚未招募不适用

Prevalence of cirrhotic cardiomyopathy and its implications in patients undergoing living donor liver transplantation - A prospective observational study

Dr Mohamed Rela1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2026年1月20日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
200
试验地点
1

研究概览

简要总结

Liver transplant is the definitive treatment for patients with end stage liver disease

Due to altered physiological condition patients with cirrhosis develop a phenomenon called cirrhotic cardiomyopathy

Cirrhotic cardiomyopathy is defined as cardiac dysfunction in patients with cirrhosis in the absence of prior cardiac disease

In 2019 the cirrhotic cardiomyopathy consortium criteria reviewed  electrophysiological changes in cirrhotic cardiomyopathy and discussed their clinical relevance and potential treatment strategies

Systolic dysfunction like left ventricular ejection fraction less than or equal to fifty percentage or absolute global longitudinal strain less than 18

Advanced diastolic dysfunction with three or more like

Septal e velocity of less than 7 

E by e prime ratio of more than or equal to 15

Left atrial volume index of more than 34

Tricuspid regurgitation velocity of more than 2.8

Along with these other condition like any changes in electrocardiography or electromechanical uncoupling or serum biomarkers

All these will be analysed by trans thoracic echocardiography in pre anaesthesia checkup and during post operative period

Cardiac changes will be analysed and any cardiac events will be noted

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 65.00 Year(s)(—)
性别
All

入选标准

  • All patients between 18 to 65 years of age who are undergoing living donor liver transplant surgery at our institution.

排除标准

  • Patient refusal Diagnosed with known cardiac disease.
  • ischaemic heart disease, valvular or structural heart disease Acute liver failure Chronic kidney disease.

研究者

发起方
Dr Mohamed Rela
申办方类型
Research institution
责任方
Principal Investigator
主要研究者

Nisha Maharu M G

Institute

研究点 (1)

Loading locations...

相似试验