Retrospective Study of Metastatic Left Colon and Rectal Cancer as Regard Treatment With Anti_EGFR Targeted Therapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 主要终点
- OS and DFS of patients with metastatic colorectal cancer patients received anti_EGFR targeted therapy
研究概览
简要总结
Colorectal cancer ranks the second lethal cancer and third prevalent malignant tumour worldwide, Despite of different odern modalities for diagnosis,large number of cases diagnosed at metastatic advanced stage .
New treatment approach has been discovered habe been discovered making a huge revolution in metastatic colorectal cancer represented by targeted therapy including anti_EGFR ,anti_angiogenic and kinase inhibitors .
详细描述
Retrospective study aims to evaluate the effect of EGFR expression in metastatic colorectal cancer and the outcome of treatment with anti_EGFR targeted therapy between left colon and rectal cancer
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age above 18
- •Performance status zero to one according to ECOG scale system
- •Histo-pathologial diagnosis adenocarcinoma of left colon or rectum.
- •Patients diagnosed with left colon and rectal cancer.
- •Patients eligible to receive chemotherapy (with renal and liver chemistry, and normal CBC.
- •Patients diagnosed with metastatic stage.
- •K-RAS wild type.
排除标准
- •Second malignancy
- •Histo-pathological types other than adenocarcinoma.
- •Right colon cancer patients.
- •Patients refused receiving anti_EGFR targeted therapy.
- •Patients with any abnormalities preventing to receive chemotherapy.
- •Early stages of colorectal cancer.
- •K-RAS mutant type.
结局指标
主要结局
OS and DFS of patients with metastatic colorectal cancer patients received anti_EGFR targeted therapy
时间窗: Anti_EGFR targeted therapy in assuit university hospitals from 2015 to 2022
Evaluation of anti-EGFR targeted therapy on metastatic cancer rectum and left colon and factors affecting response to treatment
次要结局
- Response rate (RR) in patients received chemotherapy only or with combination with targeted therapy.(The response of patients to EGFR targeted therapy in AUH at period from 2015 to 2022)
研究者
Esraa Ebrahim mohammed
Principal investigator1
Assiut University