Use of Methazolamide to Lower Intraocular Pressure
试验速览
- 阶段
- 4 期
- 状态
- 进行中（未招募）
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Percent IOP change at each follow-up Visit
研究概览
简要总结
The purpose of this study is to evaluate the effect of methazolamide, 25 mg or 50 mg tablets once a day for a week than twice a day for a week, on lowering intraocular pressure and the safety of methazolamide.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
Double
入排标准
- 年龄范围
- 50 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Males and females between 50 and 90 years old
- •Current diagnosis of open angle glaucoma (OAG) in both eyes
- •Ability to read and write in English
排除标准
- •Glaucoma other than OAG
- •Severe or end-stage glaucoma (cup to disc ratio >0.8 or Mean Deviation on Visual Field worse than -12)
- •Pregnant or breast-feeding women
研究组 & 干预措施
Methazolamide 25 mg
Once a day [q.d] in the morning for 1 week, Twice a day [b.i.d.] in the morning and evening for 1 week
干预措施: Methazolamide 25 MG (Drug)
Methazolamide 50 mg
Once a day [q.d] in the morning for 1 week, Twice a day [b.i.d.] in the morning and evening for 1 week
干预措施: Methazolamide 50 MG (Drug)
结局指标
主要结局
Percent IOP change at each follow-up Visit
时间窗: Day 1 (Pre-dosing, then 4- and 8- hours post dosing), Day 7 (Pre-dosing, then 4- and 8- hours post dosing), Day 14 (Pre-dosing, then 4- and 8- hours post dosing)
IOP measure is measured using Goldmann Tonometry. IOP is measured in mmHg with a normal range from 12 mmHg to 22 mmHg.
次要结局
未报告次要终点