Laser Biostimulation in Periodontal Treatment of Diabetic and Systemically Healthy Periodontitis Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 主要终点
- IL-1β level in GCF
研究概览
简要总结
The use of nonsurgical periodontal treatment, together with plaque control is considered the gold standart for the treatment of periodontal diseases; it produces beneficial effects such as reductions in clinical inflammation, decreases in pocket depth and increases in clinical attachment levels .However to modulate the healing response additional protocols has been suggested to increase the efficacy of existing treatment protocols. Laser biostimulation therapy is highly preferred method used due to its healing acceleration effect on several wounds in medical field. Thus,the investigators aimed to evaluate the laser biostimulation therapy adjunct to non-surgical periodontal treatment in systemically healthy and uncontrolled type 2 diabetes mellitus patients with generalized periodontitis. The effects of laser irradiation with Nd-YAG laser at the 1064-nm wavelength as an adjunct to non-surgical periodontal treatment (NSPT) was analysed by means of IL-1β and IL-10 concentrations in gingival crevicular fluid and periodontal clinical measurements of systemically healthy and uncontroled DM2 patients with generalized periodontitis.
详细描述
Today, the one that stands out the most among these protocols is laser application which was concluded to be a support or be an alternative treatment approach to standart periodontal treatments . As the laser biostimulation therapy(LBT) has been investigated by means of anti-inflammatory and healing promotion action on periodontal tissues, the LBT adjunct to non-surgical periodontal treatment of diabetic patients expected to create positive healing effects. The biostimulation effect of laser on tissue healing has drawn significant attention, not only in healthy individuals but also in patients with systemic problems causing impaired wound healing such as diabetes mellitus . Patients with poor metabolic control frequently present impaired wound healing and using LBT as a treatment method for diabetic ulcers have shown positive healing effects . However, there has been little knowledge about the additional benefits of LBT on healing proccess or inflammatory response among patients with uncontrolled diabetes mellitus type 2 receiving periodontal treatment.
In the light of the current knowledge, the impaired wound healing seen in diabetic patients may be a reason to require an additional approach in periodontal treatment like biostimulation of periodontal tissues by several ways. In order to determine the healing response, the investigators aimed to evaluate the effects of LBT irradiation with Nd-YAG laser at the 1064-nm wavelength as an adjunct to non-surgical periodontal treatment (NSPT) by means of periodontal clinical measurements and gingival crevicular fluid cytokine levels (IL-1β and IL-10) in systemically healthy and uncontroled DM2 patients with generalized periodontitis .
The study was designed as a split-mouth randomized, controlled, double-blind clinical study. The study protocol was approved by the Local Ethics Committee of Ondokuz Mayıs University and Turkey Ministry of Health, Drug and Medical Device Agency . The written informed consent was obtained from all study participants in accordance with the Helsinki Declaration .
All participants with periodontitis received NSPT. Non-surgical periodontal treatment consisted of conventional quadrant scaling in four session of 30 min, each on a weekly basis, using scalers, curettes and ultrasonic devices.
Laser Biostimulation treatment (LBT) and Sham application: Following NSPT, either the left or right side of each periodontitis patient was randomly selected (by coin toss) to receive LBT or sham treatment. LBT was performed six times (on the same day 30 which was the last scalling and root planning session and repeated weekly for 5 more times) using a 1064 nm Nd.YAG laser (Fotona AT Fidelis III,Ljubljana, Slovenia).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 35 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Volunteering to participate in the study, being male and ≥ 35 years of age,
- •Having been diagnosed as type 2 diabates mellitus (DM2) with the ADA criteria at least 2 years before the study and having an HbA1c value of ≥ 7 for DM2 group,
- •Not having a systemic disease other than DM2 for diabetic group; and not having any systemical diseases for systemically healthy group,
- •Not having any systemic complications of diabetes,
- •Not smoking or consuming alcohol,
- •Having at least 20 teeth,
- •Having at least two single-rooted teeth (like one premolar or incisor tooth) representing symmetrical or same group teeth with gingival index≥2, bleeding on probing (+), probing pocket depth and/or clinical attachment lvel >5 mm as well as ≥30% radiographically observable alveolar bone loss, on the left and right area of mandibular,
- •Being able to fulfill the instructions for oral hygiene training
排除标准
- •using systemic antimicrobials, non-steroidal anti-inflammatory drugs and/or steroids during the 6 weeks prior to data collection
- •received periodontal treatment in the 6 months prior to data collection
- •having predisposing factors such as a dental crown, bridge, filling, or cavity on teeth from which the GCF was to be collected.
结局指标
主要结局
IL-1β level in GCF
时间窗: GCF sampling was performed prior to periodontal treatment and on days 30,37,72 of follow-up.
IL-1β is a cytokine present in gingival crevicular fluid (GCF). Its concentration is calculated as picogram/microliter and it changes due to the elimination of inflammation by periodontal therapy.
IL-10 level in GCF
时间窗: GCF sampling was performed prior to periodontal treatment and on days 30,37,72 of follow-up.
IL-10 is a cytokine present in gingival crevicular fluid (GCF). Its concentration is calculated as picogram/microliter and it changes due to the elimination of inflammation by periodontal therapy.
次要结局
未报告次要终点
研究者
muge lutfioglu
Associate Professor
Ondokuz Mayıs University