A Comparative Study To Evaluate The Efficacy Of Intralesional Injections Of Triamcinolone Acetonide Versus Vitamin D3 In The Treatment Of Alopecia Areata

TITLE - A Comparative study to evaluate the efficacy of Intralesional injections of Triamcinolone acetonide versus Vitamin D3 in the treatment of Alopecia areata

BACKGROUND-

Alopecia areata is an autoimmune condition .Immune system mistakenly attacks hair follicles that leads to patches of non scarring hair loss. Exact cause of alopecia areata is not known and believed to involve a combination of genetic, environmental, and immunological factors.  Intralesional Cortiocosteroid affect local cytokine expression leading to gradual decrease in type 1 and 2 cytokines in parallel with clinical improvement suggesting direct suppression of local immune response. Vitamin D receptors (VDRs) highly expressed in keratinocytes of human hair follicles and absence of expression of VDRs associated with reduced hair follicle growth and epidermal differentiation.

MATERIAL AND METHODS - The study was a prospective, randomized, open-labeled investigation conducted over 18 months. It took place at the Department of Pharmacology, in collaboration with the Department of Dermatology, at Era’s Lucknow Medical College and Hospital in Lucknow. The research focused on patients presenting to the Dermatology outpatient department with a clinical diagnosis of alopecia areata. The sample size consisted of 72 patients, divided equally into two groups of 36 each.