Clinical Utility of Bronchoalveolar Lavage in Interstitial Lung Diseases
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 66
- 主要终点
- description of pattern and percentage of specific inflammatory cellular infiltrate in different interstitial lung diseases in bronchoalveolar lavage .
研究概览
简要总结
Interstitial lung disease (ILD) represents a various group of disorders characterized by inflammation and fibrosis within the lung parenchyma.[1] ILD refers to a group of diffuse parenchymal lung disorders, including a spectrum of conditions such as idiopathic pulmonary fibrosis (IPF), sarcoidosis, and connective tissue disease-associated ILD (CTD-ILD) characterized by inflammation and fibrosis of the interstitium.
ILD results in Impaired lung function and, in severe cases, respiratory failure.[1] Diagnosing ILD is a complex task due to the heterogeneous nature of these disorders.
Distinguishing between different ILD subtypes and identifying disease progression present ongoing challenges in clinical practice. .[2] BAL emerges as a key investigative tool , allowing for the collection of bronchoalveolar fluid.
The cellular and molecular composition of BAL fluid provides valuable insights into the underlying pathology, aiding in the differential diagnosis of ILD subtypes.
The gold standard in BAL analysis is cytological examination by microscopy.[3] Flow cytometry is an updated method of BAL analysis which can provide quicker and more objective results and, with the appropriate design of antibody panels, accurately quantify the main leukocyte subsets.
Several studies have described the usefulness of flowcytometry for the discrimination of sarcoidosis from other lymphocytic pathologies or even to perform leukocyte subset counting in diverse ILDs.[4][5]
Both microscopic and flowcytometric examination of BAL in ILD are complementary tools that provide comprehensive information about the cellular landscape of the lower respiratory tract ,conclusive for:
Accurate diagnosis
Primary aim:
Characterization of specific inflammatory cellular infiltrate in different interstitial lung diseases.
- Secondary aims:
- Correlation between clinical ,radiological and inflammatory cellular pattern as regards BAL findings of different interstitial lung diseases
- Assessment of impact on outcome, prognosis and survival of the disease as regards management modification after BAL characterization
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Clinical suspicion of ILD based on symptoms, clinical examination, and radiological findings or newly diagnosed cases .
- •HRCT findings consistent with ILD
- •Willingness to undergo bronchoscopy with BAL and provide informed consent
排除标准
- •Hemodynamic instability or ICU admission at time of evaluation
- •Oxygen saturation < 88% on room air or < 92% on oxygen therapy
- •Absolute contraindications to bronchoscopy (e.g., uncorrected bleeding diathesis, recent myocardial infarction)
- •Associated chronic chest diseases other than ILD (COPD. bronchial asthma and lung cancer )
- •Known active pulmonary infection or recent antibiotic treatment (< 2 weeks)
- •Pregnancy
结局指标
主要结局
description of pattern and percentage of specific inflammatory cellular infiltrate in different interstitial lung diseases in bronchoalveolar lavage .
时间窗: 2 years
次要结局
未报告次要终点
研究者
Maha Ahmed Abd EL Gawad Mohammed Okasha
pulmonologist at Assiut Police hospital
Assiut University