Genetic Risk Factors for Severe Asthma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- Examination of the relationship between the IL-16 promoter genotype and the presence of the asthma phenotype
研究概览
简要总结
The purpose of this study is to determine whether a specific genetic factor influences the severity of asthma symptoms.
详细描述
Asthma is one of the most common chronic diseases in the United States. It is well known that asthma susceptibility is inherited; however, it is unknown if asthma severity is heritable. Studies suggest that levels of interleukin-16 (IL-16) may influence asthma severity. This study will examine the role of differences in the control region of the IL-16 gene in a racially diverse group of asthmatics and nonasthmatics and will determine if the IL-16 gene control region is related to asthma severity.
Participants in this study will undergo lung function and blood tests; they will also complete a questionnaire about their respiratory health. Asthmatic participants will complete a severity-of-asthma questionnaire.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 44 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Examination of the relationship between the IL-16 promoter genotype and the presence of the asthma phenotype
时间窗: Throughout study
Examination of the serum IL-16 concentration and the serum IL-16:IL-9, IL-16:IL-13, and IL-16: TNF-alpha ratios as possible intermediate phenotypes lining the IL-16 promoter genotype to asthma severity
时间窗: Throughout study
Examination of the relationship between the IL-16 promoter genotype and asthma severity
时间窗: Throughout study
次要结局
- Storage of DNA from all 600 participants for future study into the determinants of asthma severity(Throughout study)