Associations and Plausibility Among Left Ventricle Diastolic Function, Serum Uric Acid and Inflammatory Biomarkers in Individuals With Cardiometabolic Risks - A Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 67
- 试验地点
- 1
- 主要终点
- Left ventricle diastolic dysfunction with elevated left atrial pressure
研究概览
简要总结
Metabolic syndrome and hyperuricemia were both associated with inflammation, leading to diversities of cardiovascular disease such as left ventricular diastolic dysfunction, but the relationship among these entities remained unclear. The aim of the present study focuses on the association among hyperuricemia, diastolic dysfunction and inflammatory biomarkers in apparently healthy individuals with metabolic syndrome
详细描述
Apparently healthy individuals with metabolic syndrome were prospectively and consecutively enrolled since August 2017. Blood samples were obtained after participants are fasting for at least 12 hours, including serum uric acid, high-sensitivity C-reactive protein, high-sensitivity interleukin-6, tumor necrotizing factor alpha, fasting glucose, glycosylated hemoglobin, insulin, lipid profile, creatinine, alanine aminotransferase, sodium, potassium, and calcium. All echocardiographic parameters were measured in accordance with the American Society of Echocardiography guidelines.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 20 to 75 years
- •Metabolic syndrome
排除标准
- •Left ventricular ejection fraction <40%
- •Severe valvular heart disease
- •Significant structure heart diseases such as hypertrophic, dilated, infiltrative or restrictive cardiomyopathy, or congenital heart disease
- •Persistent or chronic atrial fibrillation
- •Status post cardiac surgery, including coronary artery bypass surgery of valve intervention
- •Status post intra-cardiac device implantation
- •Chronic obstructive pulmonary disease
- •Severe anemia
- •An obvious systemic disease that interferes left ventricular diastolic dysfunction such as acute coronary syndrome
结局指标
主要结局
Left ventricle diastolic dysfunction with elevated left atrial pressure
时间窗: 1 day
The contemporary definition of left ventricular diastolic dysfunction with elevated left atrial pressure is mainly \>50% positive of the following criteria: (1) average E/e' ≥14 (2) left atrial volume index \>34 ml/m2 (3) tricuspid regurgitation velocity \>2.8 m/s
次要结局
- high-sensitivity C-reactive protein(1 week)
- high-sensitivity interleukin-6(1 month)
- tumor necrotizing factor alpha(1 month)
研究者
Cheng-Wei Liu
Cardiologist
National Defense Medical Center, Taiwan