Effects of Gymnemic Acids Lozenge on Reward Region Response to Receipt and Anticipated Receipt of High-Sugar Food, High-Sugar Food Pictures, and Ad Lib Candy Intake
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 主要终点
- fMRI responses to high-sugar food tastes and food cues
研究概览
简要总结
The purpose of the research is to test whether a gymnemic acids (GA) lozenge will reduce reward region response to intake of high-sugar food and ad lib candy intake and whether the GA lozenge reduced reward region response to anticipated intake of high-sugar food and high-sugar food pictures relative to a placebo lozenge.
详细描述
Test the hypothesis that an acute dose of Crave Crush will produce greater reductions in reward region response to a taste of a high-sugar/high-fat beverage and anticipated receipt of this beverage than a placebo dose.
Test the hypothesis that a dose of Crave Crush will result in reduced ad lib candy intake while the participants complete a survey after the fMRI scan. Participants will receive a second dose of Crave Crush or placebo. They will then be placed in a room to complete a few surveys. A bowl of candy will be placed on the table. Participants will be told that the candy is left over from their assessment and that they are free to have as much as they like, because the candy must be discarded after each participant.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between 18 and 50 years old
- •report having a sweet tooth
- •report desire to lose weight
- •Body Mass Index between 18 and 40
排除标准
- •major psychiatric disorders
- •serious health problems (e.g., diabetes)
- •habitual use of psychoactive drugs or medications
- •contraindications for MRI scanning (e.g., ferromagnetic braces)
- •gluten or lactose intolerance
- •a vegan diet.
研究组 & 干预措施
Crave Crush
Crave Crush is a plant-based tablet that alters taste perception by affecting sweet taste receptors on the tongue.
干预措施: Crave Crush (Dietary Supplement)
Placebo
The placebo tablet is comparable in taste and is comprised primarily of sorbitol.
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
fMRI responses to high-sugar food tastes and food cues
时间窗: 13 minutes
Blood oxygen dependent signal (BOLD) response in exposure to intake of high-sugar food and food cues will be measured during a fMRI scan to test whether the GA lozenge produces greater reductions in activity in reward-related brain regions relative to a placebo lozenge.
次要结局
- candy consumption(15 minutes)