ISRCTN14680495已完成不适用
Amongst patients having major elective colorectal surgery does intraoperative goal directed fluid therapy particularly decrease postoperative hospital length of stay in patients who are categorised high risk on the basis of a preoperative cardiopulmonary exercise test result? - a double-blind parallel-arm randomised controlled single-centre trial
Plymouth Hospitals NHS Trust (UK)0 个研究点目标入组 168 人开始时间: 2009年4月20日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 168
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Both males and females, age 18 and older
- •2. Elective colorectal surgical patients scheduled for major surgery
- •3. Patients with a measurable anaerobic threshold (AT) above 8 ml O2/kg/min
排除标准
- •1. Unwillingness to participate
- •2. Inability to perform the tests and consent within the timetable for elective surgery
- •3. Measured Anaerobic Threshold below 8 ml O2/kg/min. Such patients will be considered to be extremely unfit and as such will not be suitable for inclusion in the trial.
- •4. Withdrawn by anaesthetist or surgeon
- •5. Acute myocardial infarction (3?5 days)
- •6. Unstable angina
- •7. Uncontrolled arrhythmias causing symptoms or haemodynamic compromise
- •8. Syncope
- •9. Active endocarditis
- •10. Acute myocarditis or pericarditis
- •11. Symptomatic severe aortic stenosis
- •12. Uncontrolled heart failure
- •13. Acute pulmonary embolus or pulmonary infarction
- •14. Thrombosis of lower extremities
- •15. Suspected dissecting aneurysm
- •16. Uncontrolled asthma
- •17. Pulmonary edema
- •18. Room air desaturation at rest <85%
- •19. Respiratory failure
- •20. Acute noncardiopulmonary disorder that may affect exercise performance or be aggravated by exercise (i.e. infection, renal failure, thyrotoxicosis)
- •21. Severe oesophageal disease
- •22. Recent oesophageal or upper airway surgery
- •23. Systemic steroid medication
- •24. Bleeding diathesis
- •25. Left main coronary stenosis or its equivalent
- •26. Moderate stenotic valvular heart disease
- •27. Severe untreated arterial hypertension at rest (200 mm Hg systolic, 120 mm Hg diastolic)
- •28. Tachyarrhythmias or bradyarrhythmias
- •29. High-degree atrioventricular block
- •30. Hypertrophic cardiomyopathy
- •31. Significant pulmonary hypertension
- •32. Advanced or complicated pregnancy
- •33. Electrolyte abnormalities
- •34. Orthopaedic impairment that compromises exercise performance
研究者
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