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临床试验/NCT06372158
NCT06372158招募中不适用

Effects of Liposomal Encapsulation on Calcium Powder Absorption and Metabolism

National Yang Ming Chiao Tung University2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2024年4月8日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
20
试验地点
2
主要终点
Hematology Test

研究概览

简要总结

Compared with traditional calcium supplements, liposome calcium can increase the bioavailability of calcium and reduce the waste caused by gastric acid destruction of calcium. This allows calcium to be released slowly in the intestines, reducing the risk of indigestion or other side effects caused by excessive intake at one time. Liposomal calcium can be taken orally directly. It does not need to be dissolved in water before taking like other calcium supplements, making it more convenient to use. Based on the above advantages, liposomal calcium is a relatively safe and easy-to-absorb calcium supplement, suitable for long-term use, and can meet the body's demand for calcium. According to the recommendations of the World Health Organization, the daily calcium intake for adults should be 1000-1300 mg. In Taiwan, the seventh edition of the revised reference intake of dietary nutrients for Chinese people recommends that the daily intake for adults should be 1,000 mg. The calcium dose used in this study was 500 mg. The purpose was to explore whether the sustained-release characteristics of liposome coating technology can improve the absorption rate after consuming calcium powder and achieve better bioavailability. It is expected that microlipids made by lecithin can Lipid calcium powder increases its maintenance time in the blood, thereby increasing the supplementary effect of calcium, and is an alternative to calcium supplements.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Single (Participant)

入排标准

年龄范围
20 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Adults aged 20-60 years old, without heart, liver, kidney, endocrine or major organic diseases (patient report), and able to fully cooperate with the experiment.

排除标准

  • Patients with renal insufficiency and dialysis
  • Cancer patients
  • Underweight (BMI#17) or obese (BMI#27)
  • Those taking medications for chronic diseases
  • Blood pressure systolic blood pressure # 130 mmHg or diastolic blood pressure # 85 mmHg
  • Fasting blood glucose # 100 mg/dL
  • Fasting triglycerides # 150 mg/dL, total cholesterol # 200 mg/dL
  • Have a history of vitamin C allergy
  • People suffering from mental illness
  • Pregnant and breastfeeding women
  • Patients with hemosiderosis
  • Kidney stone patients
  • Supplements for those who take calcium for a long time

结局指标

主要结局

Hematology Test

时间窗: Day 14 and 28

Fasting blood glucose, triglycerides, total cholesterol, Blood urea nitrogen, Creatinine(Blood urea nitrogen (BUN) and creatinine tests can be used together to find the BUN-to-creatinine ratio (BUN:creatinine). A BUN-to-creatinine ratio can help your doctor check for problems, such as dehydration, that may cause abnormal BUN and creatinine levels.), GOT, GPT

General examination

时间窗: Day 14 and 28

BMI(Body Mass Index is a simple calculation using a person's height and weight. The formula is BMI = kg/m2 where kg is a person's weight in kilograms and m2 is their height in metres squared) and blood pressure

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

YenPing, Lei

Assistant professor

National Yang Ming Chiao Tung University

研究点 (2)

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