Cardiorespiratory fitness in newly diagnosed patients with Relapsing Remitting Multiple Sclerosis compared to matched healthy controls: already lagging behind from the start? - VO2max in early MS / LOW2early

Vrije Universiteit Medisch Centrum0 个研究点目标入组 32 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

暂无简介。

•MS patients
•In order to be eligible to participate in this study, the MS patients must meet all of the following criteria:
•- definite diagnosis of Relapsing Remitting MS according to the most recent international diagnostic criteria;
•- diagnosis within 12 months prior to inclusion date;
•- disease severity: EDSS score of maximal 2 with normal pyramidal and cerebellar functions (i.e. Functional Systems Score for pyramidal functions = 0 and Functional Systems Score for cerebellar functions = 0).
•- age at definite diagnosis between 18-65 years.
•Healthy Siblings/Controls (controls)
•In order to be eligible to participate in this study, the healthy controls must meet the following criteria:
•- healthy sibling of participant with MS, and matching with respect to sex, age (± 5 years), level of physical activity in the past year;
•- healthy persons, matching to MS participants with respect to sex, age (± 5 years), and level of physical activity in the past year.
•- age between 18-65 years

•- Physician-confirmed diagnosis of (other) neurological disorders or systemic or malignant neoplastic diseases.
•- Serious comorbidities precluding Cardiopulmonary Exercise test (CPET) or Lung function examination.
•- Use of heart rate regulating medication (e.g. Beta-blockers).
•- Use of medication for lung diseases.
•- Being pregnant, or receiving medical help/fertility treatment to become pregnant.
•- Body Mass Index of 30 or higher.
•- Sports and exercise activities in the past year of > 10 hours/week.
•- Does not speak Dutch.

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