A Two-arm Parallel Randomized Clinical Trial of Implementation of Technology-enabled Management Versus Usual Care for Blood Pressure

For this study, we have 3 cohorts that employ varying recruitment strategies before they are enrolled in the interventions.

At Stanford, we have 2 cohorts, where Cohort 1 is recruiting participants through clinic screening and contacting them through text or email.

For Cohort 2, recruitment is divided into two phases: Control Phase I and Intervention Phase II. During Control Phase I, standard recruitment methods were employed, including general outreach through participating clinics and pre-existing clinical networks. These efforts did not incorporate specific strategies aimed at enhancing diversity or prioritizing underrepresented populations. In contrast, Intervention Phase II introduced four targeted strategies designed to improve the inclusion of African-American, Hispanic/Latinx individuals, and women.

1. Digital Outreach via BuildClinical: The study leverages a digital recruitment campaign managed by BuildClinical, utilizing targeted online advertisements across various platforms. Prospective participants who engage with the advertisements are directed to a study landing page, where they receive detailed study information and complete a preliminary eligibility screening before being contacted by the study team.
2. Patient Registry-Based Recruitment: Eligible participants will be identified through structured data queries from the STAnford Research Repository (STARR) or EPIC registry. This approach ensures targeted outreach to individuals who meet the study's inclusion criteria while reducing screening burden.
3. Honest Broker Outreach via Stanford RPEP: To maintain privacy compliance, the Stanford Research Participant Engagement Program (RPEP) will conduct Honest Broker outreach via multiple channels, including secure Epic MyHealth messages, postal mail, and provider co-invitations. This method allows potential participants to opt in or out before direct contact with the research team, ensuring ethical and efficient recruitment.
4. Spanish-Speaking Ambassador Program: A dedicated Spanish-speaking ambassador will support recruitment efforts by engaging with Spanish-speaking participants, providing culturally tailored study information, and assisting with the informed consent process. This initiative ensures equitable access for Spanish-speaking individuals and facilitates participation among historically underrepresented populations.

Our TIDE site partners at the Morehouse School of Medicine utilize their own recruitment methods for cohort 3, which uses the following: