Feasibility Study of Mixed Reality Exergame on Performance and Cortical Outcomes in Healthy Older Adults and People With Mild Cognitive Impairment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- Single-task performance
研究概览
简要总结
The executive dysfunctions are a problem in individuals with MCI which predict conversion to dementia and is positively related to physical activity level. Previous studies found that exercise can prevent executive and physical dysfunctions for people with MCI. However, the motivation is a critical factor in supporting a sustainable exercise. Exergame is combination of exercise and video game. Enjoyment during playing an exergame can support the exercise motivation. Therefore, we will explore the feasibility of using MR exergame in people with MCI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy group: 1) MoCA score > 24; 2) Independent walking without using gait aids; 3) No diagnosis of the dementia by clinician.
- •MCI group: 1) MoCA score between 16 to 24; 2) Independent walking without using gait aids.
排除标准
- •Uncontrolled high blood pressure (more than 140/90 mmHg)
- •Hemodialysis
- •Have clinical diagnosis of the disease or symptoms that could influence the performance assessments such as arthritis or severe hand pain which reports by participants and the testing by physiotherapist before testing.
- •History of neurological disorder, such as stroke or other neurodegenerative disorder
- •Taking medicine which affected to functional movement.
- •Unable to follow study protocol.
- •Uncorrected visual or hearing impairment.
- •Positive screening for contraindication of TMS which will be confirmed by TMS screening questionnaire such as uncontrolled seizures.
研究组 & 干预措施
Mild cognitive impairment
干预措施: Mixed reality exergame (Other)
Mild cognitive impairment
干预措施: Education (Other)
Healthy older adults
干预措施: Mixed reality exergame (Other)
结局指标
主要结局
Single-task performance
时间窗: before and immediately after intervention
Box and Block Test
Dual-task performance
时间窗: before and immediately after intervention
Box and Block with Serial Sevens Test
Visual attention and task switching
时间窗: before and immediately after intervention
Trail Making Test
Inhibitory control
时间窗: before and immediately after intervention
Color-Word Stroop Test
Cortical outcomes
时间窗: before and immediately after intervention
Transcranial magnetic stimulation was used for measuring the cortical outcomes, which consist of resting motor threshold, input-output curve of motor evoked potentials recruitment and cortical silent period.
Usability
时间窗: immediately after Mixed reality exergaming
System usability scale questionnaire was used for measuring the usability of mixed reality exergame. It consists of 10-item, which are typically rated on a five-point scale. A higher SUS score generally indicates better usability.
Motivation
时间窗: immediately after Mixed reality exergaming
Intrinsic Motivation Inventory was used for measuring the motivation. It rated on seven-point scale. Higher IMI scores reflect higher levels of motivation.
Adverse side effects
时间窗: immediately after Mixed reality exergaming
Cybersickness in Virtual Reality Questionnaire was used for assessing cybersickness symptoms, including nausea, vestibular, and oculomotor. The total score is the sum of the three sub-scores. Each question is presented on a 7-item Likert Scale.
次要结局
未报告次要终点
研究者
Rommanee Rojasavastera
Principal Investigator, Faculty of Physical Therapy, Mahidol University
Mahidol University