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临床试验/NCT03162640
NCT03162640已完成不适用

Link Between Impulsivity and Time Anticipation

University Hospital, Strasbourg, France1 个研究点 分布在 1 个国家目标入组 38 人开始时间: 2017年5月5日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
38
试验地点
1
主要终点
Measure the capacities of the subjects to anticipate the apparition of the target

研究概览

简要总结

Cannabis smokers having begun prematurely their consumption (before 16 years) present a persistent impulsivity much later after have stopped their consumptions. The literature highlights that the impulsivity promotes the passage towards a compulsive consumption, and the loss of control. To explain this phenomenon, some authors hypothesized that impulsivity would lead the subjects to overestimate the duration of events and to choose immediate rewards than preferred but delayed rewards. This hypothesis questions the role of the temporal anticipation in the impulsive choices. In a first hypothesis, the temporal impulsivity could be an endogenous deficit bound to the reward, and would be responsible for disorders of the temporal anticipation. In this case, the disorders should be observed especially when the subject anticipates a reward. Alternately, a disorder of the temporal anticipation could provoke impulsivity, and in this case, would be present with or without reward. To separate these hypotheses, we propose to test the capacities of temporal anticipation of non-smokers and early smokers of cannabis by means of a behavioral task " Hazard function task ", which allow to measure the capacity of a subject to anticipate the apparition of an event on the basis of a temporal cue. The neuronal correlates will be measured by a recording EEG of the wave ' CNV ' (fix a quota for denial of variation) which reflects the temporal accumulation and the processes of anticipation.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 50 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Healthy volunteers Man or woman of age between 18 and 50 years-old
  • Absence of consumption of cannabis and tobacco for 1 year and absence of substance use disorder in history
  • Matching in age and sex to the group consumers of cannabis
  • Early consumers of cannabis (at the beginning of the consumptions before 16 years)
  • Man or woman of age between 18 and 50 years old
  • Statement of more than three consumptions a day of cannabis for at least one year and consumption of cannabis having begun before the age of 16 years.
  • Urinary analysis is positive for the presence of cannabis
  • Positive auto-questionnaire CAST: 2 positive answers to CAST questionnaire
  • Hospitalized or not

排除标准

  • Presence or history of a severe and invalidating somatic pathology (neurological, cardiovascular, lung, metabolic, renal, hepatic, gastro-intestinal)
  • History of cranial trauma with loss of consciousness.
  • substance use disorder except the substance tested in the protocol (cannabis).
  • Invalidating sensory disorders in particular visual: glaucoma, any retinal pathology. Visual acuteness 0.8
  • History of general anesthesia in the previous 3 months the study
  • Any evolutionary neurological or psychiatric pathology
  • Subject under guardianship
  • pregnancy

结局指标

主要结局

Measure the capacities of the subjects to anticipate the apparition of the target

时间窗: 8 days after inclusion in the study

on the basis of a temporal cue presented before the target, and give the response as quickly as possible after the presentation of a rewarding versus not rewarding target.

次要结局

未报告次要终点

研究者

发起方
University Hospital, Strasbourg, France
申办方类型
Other
责任方
Sponsor

研究点 (1)

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