NCT00772564已完成4 期
The Use of Statins for Myocardial Death Prevention: From Cell to Bedside
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Heart EcoCardiography and specific laboratory tests
研究概览
简要总结
The administration of high dose HMG-CoA reductase inhibitors (Statins) to patients with acute ST-elevation MI (hypoxia/ischemia) who are treated with primary PCI (reoxygenation/ reperfusion) will protect their cardiomyocytes from death and thus preserve LV ejection fraction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients suffering from acute ST elevation resulting from myocardial infarction, Killip Classification 1 and 2 will be included at-random to either group. Included subjects should be able to give their informed consent to participate in this study.
排除标准
- •The impossibility to give the required informed consent.
- •Known allergy to Atorvastatin.
- •Base line serum creatinine of 1.4 mg/dL.
- •Killip Classification 3 and
- •Persisting vomiting.
- •History of previous liver disease.
- •History of previous muscle disease or rabdomyolisis.
- •Treated already with high dose atorvastatin
- •Non Compliance.
研究组 & 干预措施
Atorvastatin 80 mg
Experimental
干预措施: Atorvastatin (Drug)
Atorvastatin 10 mg
Experimental
干预措施: Atorvastatin (Drug)
结局指标
主要结局
Heart EcoCardiography and specific laboratory tests
时间窗: Base line, second day and 60 days after myocardial infarction
次要结局
未报告次要终点
研究者
N_Krivoy
Clinical Pharmacology Unit
Rambam Health Care Campus
研究点 (1)
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