Increased Extravascular Lung Water in Asymptomatic Open-water Swimmers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 609
- 试验地点
- 2
- 主要终点
- Interstitial syndrome assessed by lung ultrasound (yes/no)
研究概览
简要总结
Previous studies suggest that increased extravascular lung water might be found in open water swimmers without respiratory symptoms. This study aims to investigate a large number of asymptomatic individuals after an open-water swimming race to assess the prevalence of increased extravascular lung water in asymptomatic open-water swimmers.
详细描述
Swimming-induced pulmonary edema (SIPE) can occur during open-water swimming. The pathophysiological mechanisms are still partly unknown, but central pooling of blood volume and peripheral vasoconstriction have been suggested as important factors. SIPE is characterized by acute onset of dyspnea and cough, sometimes with excessive sputum and hemoptysis. The condition usually resolves spontaneously, but medical attention can be required in more severe cases.
Previous studies suggest that SIPE is diagnosed by clinical symptoms, decreased peripheral oxygen saturation and signs of pulmonary edema on lung ultrasound. Interestingly, signs of increased extravascular lung water have been found in divers without respiratory symptoms. There are no similar studies regarding open-water swimmers.
This study aims to investigate a large number of swimmers without respiratory symptoms after finishing an open-water swimming race. Prevalence and amount of increased extravascular lung water after swimming will be assessed by lung ultrasound. In addition, individual baseline factors and information about the race associated with increased extravascular lung water will be evaluated. This study will provide better understanding of the pathophysiological mechanism of SIPE.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Completion of an open-water swimming race during the "Vansbrosimningen" open-water swimming event
- •No respiratory symptoms (dyspnea and/or cough) during or right after the race
- •Age ≥ 18 years
排除标准
- •Presence of respiratory symptoms (dyspnea and/or cough) during or right after the swimming race
- •Declines participation
研究组 & 干预措施
Asymptomatic swimmers
Swimmers (18 years or older) finishing an open-water swimming race during the "Vansbrosimningen" open water swimming event, Sweden, without respiratory symptoms.
干预措施: Lung ultrasound (Diagnostic Test)
Asymptomatic swimmers
Swimmers (18 years or older) finishing an open-water swimming race during the "Vansbrosimningen" open water swimming event, Sweden, without respiratory symptoms.
干预措施: Peripheral oxygen saturation (Diagnostic Test)
Asymptomatic swimmers
Swimmers (18 years or older) finishing an open-water swimming race during the "Vansbrosimningen" open water swimming event, Sweden, without respiratory symptoms.
干预措施: Lung auscultation (Diagnostic Test)
Asymptomatic swimmers
Swimmers (18 years or older) finishing an open-water swimming race during the "Vansbrosimningen" open water swimming event, Sweden, without respiratory symptoms.
干预措施: Body temperature (Diagnostic Test)
结局指标
主要结局
Interstitial syndrome assessed by lung ultrasound (yes/no)
时间窗: Within 1 hour after termination of swimming
Four chest regions for both lungs are scanned by lung ultrasound; a positive region defined by the presence of three or more B-line artifacts. Bilateral or unilateral presence of two or more positive regions define positive interstitial syndrome.
Number of regions presenting B-lines on lung ultrasound
时间窗: Within 1 hour after termination of swimming
Four chest regions for both lungs are scanned by lung ultrasound; a positive region defined by the presence of three or more B-line artifacts. Assessment of the total number of positive regions.
Absolute number of B-lines on lung ultrasound
时间窗: Within 1 hour after termination of swimming
Four chest regions for both lungs are scanned by lung ultrasound; the absolute number of B-lines in each region is counted.
次要结局
- Absolute number of B-lines on lung ultrasound(At baseline 2-4 hours before swimming)
- Perceived exertion during swimming(Within 1 hour after termination of swimming)
- Number of regions presenting B-lines on lung ultrasound(At follow up within 4 hours after termination of swimming)
- Peripheral oxygen saturation(At baseline 2-4 hours before swimming.)
- Presence of crackles on lung auscultation (yes/no)(Within 1 hour after termination of swimming)
- Body temperature(At baseline 2-4 hours before swimming.)
- Interstitial syndrome assessed by lung ultrasound (yes/no)(At follow up within 4 hours after termination of swimming)
- Peripheral oxygen saturation(Within 1 hour after termination of swimming)
- Body temperature(Within 1 hour after termination of swimming)
- Absolute number of B-lines on lung ultrasound(At follow up within 4 hours after termination of swimming)
研究者
Maria Hårdstedt
Dr. Maria Hårdstedt, PhD, Specialist Internal Medicine
Dalarna County Council, Sweden