A Study On The Prediction of Neoadjuvant Efficacy And Heterogeneity For Rectal Cancer Based On MR Cytometry Imaging and Deep-radiomics
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- progression-free survival
研究概览
简要总结
This study employed MR cytometry imaging combined with deep-radiomic research methods to predict the heterogeneity of rectal cancer, and constructed a model to predict the sensitivity to neoadjuvant therapy and potential mechanisms, assisting clinicians in early identification of high-risk tumors and patients with treatment-susceptible rectal cancer, and selecting individualized treatment plans, thereby improving patient prognosis. To this end, the investigators need to collect the clinical diagnosis and treatment data of patients, surgical and biopsy pathological information, pre-treatment rectal MRI images and colonoscopy biopsy tissue sections, and follow up on the surgical pathological results and recurrence of patients. This study is a non-interventional diagnostic study, which does not interfere with the routine diagnosis and treatment of patients, does not affect any medical rights of patients, and does not increase any medical risks.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Newly diagnosed rectal adenocarcinoma without previous treatment
- •Complete radical surgery in the institute
- •Complete rectal MRI within 2 weeks before surgery
排除标准
- •Concomitant malignancies or systemic disease
- •Inadequate MR image quality for analysis
- •Incomplete clinicopathological data
- •Loss of follow-up
结局指标
主要结局
progression-free survival
时间窗: From date of surgery until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 60 months
Pathological complete response
时间窗: One month after surgery
Pathological tumor regression grade
时间窗: One month after surgery
次要结局
- Pathological differentiation grade(One month after surgery)
