跳至主要内容
临床试验/NCT07107815
NCT07107815Enrolling By Invitation不适用

A Study On The Prediction of Neoadjuvant Efficacy And Heterogeneity For Rectal Cancer Based On MR Cytometry Imaging and Deep-radiomics

Cancer Institute and Hospital, Chinese Academy of Medical Sciences1 个研究点 分布在 1 个国家目标入组 250 人开始时间: 2025年3月15日最近更新:

试验速览

阶段
不适用
状态
Enrolling By Invitation
入组人数
250
试验地点
1
主要终点
progression-free survival

研究概览

简要总结

This study employed MR cytometry imaging combined with deep-radiomic research methods to predict the heterogeneity of rectal cancer, and constructed a model to predict the sensitivity to neoadjuvant therapy and potential mechanisms, assisting clinicians in early identification of high-risk tumors and patients with treatment-susceptible rectal cancer, and selecting individualized treatment plans, thereby improving patient prognosis. To this end, the investigators need to collect the clinical diagnosis and treatment data of patients, surgical and biopsy pathological information, pre-treatment rectal MRI images and colonoscopy biopsy tissue sections, and follow up on the surgical pathological results and recurrence of patients. This study is a non-interventional diagnostic study, which does not interfere with the routine diagnosis and treatment of patients, does not affect any medical rights of patients, and does not increase any medical risks.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

性别
All
接受健康志愿者

入选标准

  • Newly diagnosed rectal adenocarcinoma without previous treatment
  • Complete radical surgery in the institute
  • Complete rectal MRI within 2 weeks before surgery

排除标准

  • Concomitant malignancies or systemic disease
  • Inadequate MR image quality for analysis
  • Incomplete clinicopathological data
  • Loss of follow-up

结局指标

主要结局

progression-free survival

时间窗: From date of surgery until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 60 months

Pathological complete response

时间窗: One month after surgery

Pathological tumor regression grade

时间窗: One month after surgery

次要结局

  • Pathological differentiation grade(One month after surgery)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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