Dynamic Changes of Circulatory and Respiratory Function After Thrombolysis in Patients With Acute Pulmonary Embolism
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- cardiopulmonary function changes
研究概览
简要总结
The investigators expect to enroll about 80-100 acute pulmonary embolism patients treated with thrombolysis in two hospitals. Dynamic changes of cardiopulmonary function after thrombolysis are detected to evaluate which indicators can quickly reflect the effectiveness of thrombolysis.
详细描述
About 80-100 acute pulmonary embolism(APE) patients treated with thrombolysis are enrolled in the First Affiliated Hospital with Nanjing Medical University and Nanjing Drum Town Hospital from January 1, 2020, to June 30, 2024. According to the 2019 ESC guideline, the standards for thrombolysis in APE patients are as follows: within 2 weeks of onset; high-risk pulmonary embolism; medium-high-risk pulmonary embolism with symptoms of aggravation.
Investigators dynamically monitor cardiopulmonary function of participants after thrombolysis, including blood pressure, heart rate, respiratory rate, blood gas analysis, 2-dimensional echocardiography (left and right ventricular diameter, pulmonary artery pressure, interventricular septum) and laboratory tests (cTnT,pro-BNP).participants are divided into two groups: thrombolytic success group and thrombolytic failure group according the previously reported criterion which is evaluated 48h after thrombolysis.
Cardiopulmonary characteristics are analyzed to seek accurate and rapid index to reflect success of thrombolysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •medium-high risk or high risk pulmonary embolism and treated with thrombolysis
排除标准
- •lack of radiologic evidence to diagnose APE
- •death within 48 hours after thrombolytic therapy
- •unable to partner treatment and leaving hospitals
- •missing other necessary data
- •pregnancy
结局指标
主要结局
cardiopulmonary function changes
时间窗: 48 hours after thrombolysis
changes of PO2，SBP，HR, cardiac ultrasound index and vasoactive drug dosage
次要结局
未报告次要终点
研究者
Bin He
Attending physician of Affiliated Hospital of Nanjing Medical University
Nanjing Medical University