NCT00035074已完成不适用
A Pharmacokinetic Study to Determine the Oral Bioavailability of Methotrexate in Patients With Inflammatory Bowel Disease
National Center for Research Resources (NCRR)1 个研究点 分布在 1 个国家开始时间: 2002年5月3日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 试验地点
- 1
研究概览
简要总结
Patients with inflammatory bowel disease (IBD) who require methotrexate (MTX)for treatment currently receive this drug by injection. MTX is also available as a pill that can be given by mouth but it is not known how well the drug enters the body in patients with Crohn's disease or ulcerative colitis. This study is being done to compare how much MTX enters the body when the drug is taken by mouth compared to when it is given by injection. If the drug is well absorbed, it may allow patients to receive the drug by mouth.
研究设计
- 研究类型
- Interventional
- 干预模型
- Crossover
- 主要目的
- Treatment
入排标准
- 年龄范围
- 0 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult or pediatric patients with IBD (CD or UC) currently receiving MTX as part of their clinical care.
- •Patients must be receiving weekly MTX at a dose between 7.5 and 40 mg/m
- •Weight >= 12 kg.
- •Normal serum creatinine.
排除标准
- 未提供
研究者
研究点 (1)
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