Is Cortical Motor Neuron Dysfunction the Underlying Mechanism of Fatigue in Fibromyalgia?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 37
- 试验地点
- 2
- 主要终点
- V-wave
研究概览
简要总结
The goal of this study is to test whether cortical motor neuron dysfunction plays a role in the pathogenesis of fatigue in fibromyalgia patients.
The main questions it aims to answer are:
Do fibromyalgia patients have lower v-wave compared to healthy subjects? Does cheering affect V-wave in fibromyalgia patients more than healthy subjects? Researchers will compare the V-waves of fibromyalgia patients with those of healthy subjects.
详细描述
All volunteers will first undergo the Fatigue Severity Scale (FSS) assessment, grip strength measurement, and a 4-meter walking speed test. Subsequently, V-wave recordings will be performed.
EMG and Force Data Acquisition
Surface EMG from the soleus muscle and force sensor data will be collected at a 2 kHz sampling rate using a data acquisition system (CED 3601 Power 1401 MKII digital-to-analogue converter and CED 1902 Quad System MKIII amplifier). Data analyses will be performed using Spike2 version 7.20 software.
Maximal plantar flexion will be performed against a force platform equipped with a force sensor (FC2231-0000-0100-L Compression Load Sensor, France) mounted on a wall and connected to a data acquisition device. Participants will be fixed to the examination table using a pelvic strap to prevent cranial movement during the contraction. This setup will allow real-time recording of muscle force during the 1-minute isometric contraction.
V-Wave Measurement Procedure
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Diagnosed with fibromyalgia according to acr 2016 criteria(for fibromyalgia group)
- •Being healthy(for control group)
- •18-60 years old
- •Volunteering
- •Being female
- •Right hand dominant
排除标准
- •Presence of scars, dermatitis, or similar conditions on the skin where surface EMG electrodes will be placed.
- •Diseases causing muscle and nerve dysfunction: myopathies, polyneuropathy, radiculopathy, peripheral nerve lesions such as entrapment neuropathies; central nervous system disorders such as stroke, amyotrophic lateral sclerosis, multiple sclerosis, and parkinsonism.
- •Hypertension and cardiac arrhythmias.
- •Other diseases with fatigue symptoms: cardiopulmonary diseases, hypothyroidism, polymyalgia rheumatica, major depression, bipolar disorder, chronic fatigue syndrome.
研究组 & 干预措施
Fibromyalgia
Subjects with diagnosed fibromyalgia will be in this arm. Subjects will have their grip strength and 4-meter walking speed measured and will be asked to fill the fatigue severity scale.
Subjects will be tested for v-wave during voluntary foot plantarflexion.
干预措施: Cheer (Other)
Healthy
Healthy subjects will be in this arm. Subjects will have their grip strength and 4-meter walking speed measured and will be asked to score the fatigue severity scale.
Subjects will be tested for v-wave during voluntary foot plantarflexion.
干预措施: Cheer (Other)
结局指标
主要结局
V-wave
时间窗: On the day of testing
Subjects will be asked to perform voluntary foot plantar flexion. During 3rd, 20th, 40th, and 60th seconds v-wave will be measured. During the 60th second of voluntary foot plantar flexion subjects will be cheered to increase their flexion strength. V-wave/H-max ratio and V-wave amplitude changes during cheer will be compared between healthy and fibromyalgia subjects. A low ratio or amplitude will be interpreted in favor of fatigue.
次要结局
- Grip strength(On the day of testing)
- Fatigue severity scale(On the day of testing)
- 4m walking speed(On the day of testing)
研究者
Fuat Orhun Alayoglu
Resident Doctor
Istanbul Physical Medicine Rehabilitation Training and Research Hospital